Streamson C. Chua, Jr.

Associate Professor of Pediatrics


Streamson Chua, M.D., Ph.D.

CONTACT INFORMATION
Office Address: Columbia University
Russ Berrie Medical Science Bldg.
1150 St. Nicholas Avenue 6th Floor
New York, New York 10032
Phone: (212) 851-5314
Fax: (212) 851-5306




Positions

1984 Intern in Pediatrics, New York Hospital, New York.
1985-87 Postdoctoral Fellow; Dept. of Molecular Endocrinology, Cornell Univ. Med. College, New York.
1987 Research Associate, Laboratory of Human Behavior & Metabolism, The Rockefeller University, New York.
1988 Associate Physician, The Rockefeller University Hospital, New York.
1992-97 Assistant Professor, Rockefeller University, New York.
1997-present Associate Professor of Pediatrics, Columbia University, College of Physicians & Surgeons, NY.

Honors

1994-95 International Life Sciences Institute of North America Future Leaders Award.
1995-2000 Irma T. Hirschl/Monique Weill Caulier Trust Fellowship Award.

Member

1999 Special Emphasis Panel Review Committee, Clinical Nutrition Research Unit Core Centers
1999-present Metabolism Study Section, NIH
2001-2005 Editorial Board: Journal of Clinical Endocrinology and Metabolism

Selected Peer-reviewed Publications

  1. Wajnrajch, M.P., Gertner, J.M., Harbison, M.D., Chua, S.C., and Leibel, R.L. Nonsense mutation in the human growth hormone releasing hormone receptor (GHRHR) causes growth failure analogous to that of the little (lit) mouse. Nature Genetics. 12(1):88-90, 1996.
  2. Chua, S.C., W.K. Chung, X.S. Wu-Peng, Y. Zhang, S-M. Liu, L. Tartaglia, and R.L. Leibel. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 27:994-996, 1996.
  3. Chua, S.C., D.W. White, L. Power-Kehoe, X.S. Wu-Peng, S-M. Liu, N. Okada, E.E. Kershaw, L.A. Tartaglia, and R.L. Leibel. Phenotypes of fatty due to Gln269Pro mutation in the Leptin Receptor (Lepr). Diabetes. 45:1141-1143, 1996.
  4. Wu-Peng, X.S., S.C. Chua, N. Okada, S-M. Liu, M. Nicholson and R.L. Leibel. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the Leptin receptor (Lepr): evidence for deficient plasma to CSF transport of Leptin in both Zucker and Koletsky obese rat. Diabetes, 46:513-518, 1997.
  5. Chung, W.K., M. Zheng, M. Chua, E. Kershaw, L. Power-Kehoe, I. Tsuji, X.S.Wu-Peng, J. Williams, S.C. Chua and R.L. Leibel. Genetic modifiers of Lepr-fa which alter susceptibility to NIDDM. Genomics, 41:332-344, 1997.
  6. Wave, M.L., J.W. Fox, J.L. Gonzalez, N.M. Davis, L deRouvroit, C.J. Russo, S.C. Chua, A.M. Goffinet and C.A. Walsh. Abberant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse. Neuron, 19:239-249, 1997.
  7. Chua, S.C., I.K. Koutras, L. Han, S-M. Liu, J. Kay, S.J. Young, W.K. Chung and R.L. Leibel. Fine structure of the murine leptin receptor gene: Splice site suppression is required to form two alternatively spliced transcripts. Genomics. 45:264-270, 1997.
  8. Kowalski, T.J., T.A. Houpt, J.W. Jahng, N. Okada, S.C. Chua, G.P. Smith, Ontogeny of Neuropeptide Y expression in response to deprivation in lean Zucker rat pups, Amer J. Physiol. 275:R466-470, 1998.
  9. Schreyer, S.A., S.C. Chua, and R.C. LeBoeuf, Obesity and Diabetes in TNF-alpha Receptor Deficient Mice. J Clin Invest. 102:402-411, 1998.
  10. Liu, S-M., RL Leibel and S.C Chua. Partial Duplication of the Lepr db-Pas Mutation is a Result of Unqueal Crossing Over. Mammalian Genome, 9:780-81, 1998.
  11. Kowalski, T.J., T.A. Houpt, J. Jahng, N. Okada, S-M Liu, S.C. Chua, and G.P. Smith. Neuropeptide Y Overexpression in the Preweanling Zucker (fa/fa) rat. Physiol Behav. 67:521-5, 1999.
  12. Korner, J., S.C. Chua, J.A. Williams, R.L. Leibel, S.L. Wardlaw. Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 70:377-383, 1999.
  13. Brown, J.A., S.C. Chua, S-M Liu, M.T. Andrews and J.G. Vandenbergh. A Spontaneous Mutation in the db gene results in obesity and diabetes in the CD-1 Outbred Mice. Am J Physiol Regul Integr Comp Physiol. 278:R320-R330, 2000.
  14. Wildman, H.F., S.C. Chua, R.L. Leibel and G.P.Smith. Effects of leptin and cholecystokinin in rats with a null mutation of the leptin receptor Lepr(fak). Am J Physiol Regul Integr Comp Physiol. 278:R1518-R1523, 2000.
  15. Korner J., S.L. Wardlaw, S.M. Liu, I.M. Conwell, R.L. Leibel, and S.C. Chua, Jr. Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-fa-f) rats. Endocrinology. 141:2465-71, 2000.
  16. Kowalski, T.J., S.M. Liu, R.L. Leibel, and S.C. Chua, Jr. Transgenic complementation of leptin receptor deficiency - I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes, 50:425-435, 2001.
  17. Hsing, A.W., S.C. Chua, Jr., Y.-Y. Gao, E. Gentzschein, L. Chang, J. Deng, and F.Z. Stanczyk. Prostate cancer risk and serum levels of insulin and leptin: A population-based study. J Natl Cancer Inst, 93:783-789, 2001.
  18. Ko, C., Lee, T.-L., Lau, P.W., Li, J., Davis, B.T., Voyiaziakis, E., Allison, D.B., Chua, S.C., Jr., Huang, L.-H. Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels. J Lipid Res. 42:844-55, 2001.
  19. Korner, J., E. Savontaus, S.C. Chua, Jr., R.L. Leibel, and S.L. Wardlaw. Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J. Neuroendocrinology, 13:959-966, 2001.
  20. Chua, S.C., S.M. Liu, Q. Li, L. Yang, V.T. Thassanapaff, and P. Fisher. Two novel congenic strains of diabetes (FVB-Lepr) and obese (DBA-Lep) with differential beta cell responses to hyperglycemia and insulin resistance. Diabetologia, 45:976-990, 2002.
  21. Hsing, A.W., Y.-T. Gao, S.C. Chua, Jr., J. Deng, and F.Z. Stanczyk. Insulin resistance and prostate cancer risk. J Natl Cancer Inst, 95:67-71, 2003
  22. Ho GY, Melman A, Liu SM, Li M, Yu H, Negassa A, Burk RD, Hsing AW, Ghavamian R, Chua SC Jr. Polymorphism of the insulin gene is associated with increased prostate cancer risk. Br J Cancer. 88(2):263-9, 2003.
  23. Levin BE, Dunn-Meynell AA, McMinn JE, Alperovich M, Cunningham-Bussel A, Chua Jr SC. A new obesity-prone, glucose intolerant rat strain (F.DIO). Am J Physiol Regul Integr Comp Physiol. 285(5):R1184-91, 2003
  24. Chua, SC, S.M. Liu, Q. Li, A. Sun, W.F., DeNino, S.B. Heymsfield, and X.E. Guo. Transgenic complementation of leptin receptor deficiency II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertiltiy/lactation in Lepr-db/db mice. AJP, Endocrinology and Metabolism, 286:E384-E392, 2004.
  25. Tortoriello, D, JE McMinn, SC Chua, Dietary induced obesity and hypothalamic infertility in DBA/2J female mice, Endocrinology, 145:1238-1247, 2004.
  26. Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML., Genetic Background (C57BL/6J Versus FVB/N) Strongly Influences the Severity of Diabetes and Insulin Resistance in ob/ob Mice. Endocrinology, 145:3258-3264, 2004.
  27. McMinn. J.E, Liu, S.-M., Dragatsis, I., Dietrich, P., Ludwig, T, and Chua, S.C., New mutant leptin receptor alleles generated by CRE and FLP recombinases, Mammalian Genome, in press, 2004.
  28. Savontaus, E., Breen, T.L., Kim, A., Chua, S.C., and Wardlaw, S.L., Metabolic effects of transgenic MSH overexpression in lean and obese mice. Endocrinology, 145:3881-3891, 2004.
  29. Balthasar, N., Coppari, R., Lee, C.E., Tang, V., Kenny, C.D., McGovern, R.A., Chua, S.C., Elmquist, J.K., and Lowell, B.B., Leptin receptor signalling in POMC neurons is required for normal body weight homeostasis. Neuron, 42:983-991, 2004.

Reviews, Chapters, and Editorials

  1. Chua, S.C. and R.L. Leibel. Obesity genes: Molecular and metabolic mechanisms. Diabetes Reviews, 5:2-7, 1996.
  2. Chua, S.C., Models of Monogenic Obesity. Behavioral Genetics, 27:277-284, 1997.
  3. Leibel, R.L. S.C. Chua and M. Rosenbaum, Obesity: The Molecular Physiology of Weight Regulation, in The Metabolic and Molecular Bases of Inherited Disease, VIII Edit., C.R. Scriver, A.L. Beaudel, W.S.Slu and D. Valle, edit. 2001.
  4. Chua, S.C., and R.L. Leibel, Body Weight Regulation: Neural, Endocrine, and Autocrine Mechanisms, in Obesity: Theory and Therapy, ed. Albert J. J. Stunkard and Thomas A. Wadden, Lippincott-Raven, 2002.
  5. Chua, S.C., Jr., K. Graham, and R.L. Leibel. Mouse models of Genetic Obesity, in Handbook of Obesity, Eds., Bray GA, Bouchard C, James, WPT, Marcel Dekker, Inc., New York, 2003.
  6. Moran TH, Langhans W, Chua S, Geary N. A special issue of reviews on ingestive science. Physiol Behav. 81:175-7, 2004.
  7. Chua SC Molecular and cellular correlates of the developmental acquisition of mechanisms modulating ingestive behavior. Physiol Behav. 82:145-147, 2004.

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