Simon Klebanov, Ph.D.

Academic Training

Department of Biophysics, Leningrad
Polytechnic Institute, St.-Petersburg, Russia.
M.S.1989
Department of Physiology, Graduate School of Biomedical Sciences
The University of Texas Health Science Center at San Antonio.
Thesis title: Effects of Food Restriction on Cardiac Biochemistry,
Mechanics and Energetics. Sponsor: Dr. Jeremiah Herlihy
The thesis resulted in three (ref. 5, 6 and 11) publications
Ph.D.1996

Traineeship

Postdoctoral associate at The Jackson Laboratory                     06/1997-11/2001

Academic Appointments

Teaching Assistant, Department of Physiology,
The University of Texas Health Science Center at San Antonio
  01/1992 - 08/1996

Hospital Appointments

Research Associate, Department of Medicine,
St. Luke's-Roosevelt Hospital Center
                           From 11/2001

Honors

Invited talk: Klebanov, S. "Murine chromosomal regions that increase maximal life span". 51st Annual Meeting of the Gerontological Society of America. Nov. 20-24, 1998. Gerontologist, Special Issue II, 38:14, 1998.

Current Support

"Life extension by caloric restriction: role of leptin". PI. NIH, NIA $200,000/year      08/2001 - 07/2005
$200,000/year

Past Fellowship and Grant Support

Chimera between ob/ob and +/+ mice: a model of primary obesity. PI.
NY Obesity Research Center
     01/2000 - 12/2001
$20,000
NRSA postdoctoral fellowship. PI.
NIH, NICHD
     07/1999 - 01/2001
Fellowship for graduate trainees in gerontology. PI.
NIH, NIA
     03/1994 - 02/1996
Intramural grant for a pilot study on effects of long-term
food restriction on cardiac mechanics and energetics. PI.
UTHSCSA
     01/1995-12/1995
$5,000
Intramural grant for a pilot study on effects of long-term
food restriction on cardiac myosin composition. PI.
UTHSCSA
     01/1994-12/1994
$4,000

Teaching Experience and Responsibilities

Teaching assistant, Physiology labs for medical students.

Other Professional Activities

Guest reviewer for "Mechanisms of Aging and Development", "Journal of Gerontology", "Growth, Development and Aging", "Obesity Research", and "Aging Cell"

Papers Published in Peer Reviewed Journals

  1. Klebanov S.E., Berman A.L., Bochina Yu.M. 1991 The construction of an evolutionary tree for signal receptor proteins. Zhurnal Evoliutsionnoi Biokhimii I Fiziologii 27(2):134. [Russian]
  2. Klebanov S.E., Bochina Yu.M., Berman A.L. 1991 A method for determining the classification of a protein in a given family at a low level of similarity. Zhurnal Evoliutsionnoi Biokhimii I Fiziologii 27(1):75. [Russian]
  3. Klebanov S.E., Bochina Yu.M., Berman A.L. 1991 A comparison of the cDNA of the sequences of signal receptor proteins. Zhurnal Evoliutsionnoi Biokhimii I Fiziologii 27(3):289. [Russian]
  4. Klebanov S., Diais, S., Stavinoha W., Suh Y., Nelson J.F. 1995 Food restriction, elevated plasma corticosterone and attenuated inflammatory response to carrageenan in male BALB/c mice. J. Gerontol. 50:B78-B82.
  5. Klebanov S., Herlihy, J.T. 1997 Effects of long-term food restriction on cardiac myosin composition. J. Gerontol. 52A:B184-B189.
  6. Klebanov S., Herlihy, J.T., Freeman G.L. 1997 Effects of long-term food restriction on cardiac mechanics. Am. J. Physiol. 273 (Heart and Circ. Physiol. 42): H2333-H2342
  7. Klebanov S, Flurkey K, Roderick TH, Archer JR, Astle MC, Chen J, Harrison, DE. 2000 Heritability of life span in mice and its implication for direct and indirect selection for longevity. Genetica 110:209-218
  8. Allison DB, Miller RA, Austad SN, Bouchard C, Leibel R, Klebanov S, Johnson T, Harrison DE. 2001 Genetic variability in responses to caloric restriction in animals and in regulation of metabolism and obesity in humans. J. Gerontol. 56A(special issue):55-65.
  9. Klebanov S, Astle MC, Roderick T, Flurkey K, Archer J, Chen J, Harrison, DE. 2001 Maximum life spans in mice are extended by wild strain alleles. Exp Biol Med 226: 854-859.
  10. Klebanov S, Harrison DE. 2002 Optimizing detection of QTLs retarding aging: choice of statistical model and animal requirements. Mech Aging Dev 123:131-144
  11. Klebanov S., Herlihy, J.T., Freeman, G.L. 2002 Assessing effects of long-term food restriction on myocardial energetics in the isolated heart preparation. Mech Aging Dev 123:1375-1388.
  12. Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE. 2003. Sexual differentiation, pregnancy, calorie restriction, and aging affect adipocyte-specific secretory protein adipocyte complement-related protein of 30 kDa (Acrp30)/Adiponectin. Diabetes 52:268-276.

Abstracts

  1. Klebanov, S., Diais, S., Stavinoha, W., Suh, Y., and Nelson, J.F. 1993. Food restriction, elevated plasma corticosterone and an attenuated inflammatory response to carrageenan in male BALB/c mice. (Slide presentation at the 46 th Annual Meeting of Gerontological Society of America.)
  2. Klebanov, S., Kim, I.S., Herlihy J.T., 1995. Age and food restriction alter cardiac myosin isozyme pattern. FASEB J. 9:A352.
  3. Klebanov, S, Kim, I.S., Herlihy, J.T. 1995. Parallelism between the effects of food restriction (FR) on longevity and cardiac myosin isozyme (CM) profile. Gerontologist 35:Special Issue I, pp 9, 240, 399.
  4. Klebanov, S., Freeman, G.L., Herlihy, J.T. 1996. Long term calorie restriction (CR) alters cardiac mechanics and energetics. FASEB J. 10:A541.
  5. Klebanov, S., Harrison, D.E. 1999. Genetic determinants of timing of multiple developmental traits. Gerontologist 39:Special Issue I, p 149.

Technical Experience
  1. Measurements of food consumption and keeping animals on food restricted regimen.
  2. Radioimmunoassay of steroid and polypeptide hormones.
  3. Free steroid hormone measurement.
  4. Measurements of foot pad edema.
  5. Tumor biology.
  6. Comparative analysis of proteins and DNA sequence similarities.
  7. Computer programming (Pascal).
  8. Native gel electrophoresis.
  9. Isolated heart preparation: mechanics and energetics.
  10. QTL analysis.
  11. Fat transplantation technique

Invited Talks

  1. Herlihy, J.T., Klebanov, S., Kim, I.S. Modulation of age-related changes in heart by diet and exercise. American Aging Association 25th Annual Meeting, p.4
  2. Klebanov, S. "Murine chromosomal regions that increase maximal life span". 51st Annual Meeting of the Gerontological Society of America. Nov. 20-24, 1998. Gerontologist, Special Issue II, 38:14, 1998.
  3. Klebanov, S. "Caloric restriction clinical implications advisory group". NIH Advisory Committee. March 8-10, 1999.

Guest Reviewer

  1. Journal of Gerontology
  2. Growth, Development and Aging
  3. Mechanisms of Aging and Development
  4. Obesity Research
  5. Aging Cell

Personal Interests

Dancing. Reading. Talking.

Mentorship Activities

Jason BurwinSummer 1998Admitted to Columbia University
Matthew MrazekSummer 1999Admitted to Stanford University
Chance YohmanSummer 1999
Sung Min Park2002-2003
Yehuda Cohen2002-2003Admitted to SUNY Downstate Med Sch.
Darshan Doshi2002-2004


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