Rudolph L. Leibel, Professor of Pediatrics and Medicine

Rudolph L. Leibel

Professor of Pediatrics and Medicine


Positions and Employment

1969-71 Major,U.S. Army Medical Corps
1972-74 NIH Clinical & Research Fellow in Pediatric Endocrinology-Metabolism, Mass. General Hospital
1975-78 Research Associate, Dept. of Nutrition & Food Science, Massachusetts Institute of Technology
1978-81 Rockefeller Scholar in Clinical Science, Rockefeller University
1972-74 Instructor in Pediatrics, Massachusetts General Hospital, Harvard University Medical School
1974-78 Asst Professor of Pediatrics, Massachusetts General Hospital, Harvard University Medical School
1978-97 Assistant Professor, Associate Professor, Head of Laboratory, Rockefeller University
Professor of Pediatrics, Cornell University Medical College
1994- Deputy Director, New York Obesity Research Center
Adjunct Professor, Rockefeller University
Professor of Pediatrics and Medicine, Head, Div. of Molecular Genetics, Columbia University
1998- Co-Director, Naomi Berrie Diabetes Center, Columbia University

Other Experience and Professional Memberships

Editorial Boards

Honors (Selected)

Patents

Selected Publications (from 1996)

  1. Wajnrajch, M.P., Gertner, J.M., Harbison, M.D., Chua Jr, S.C., & Leibel, R.L. Nonsense mutation in human growth hormone releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nature Genetics. 12(1):88-90, 1996.
  2. Chua, S.C., W.K. Chung, X.S. Wu-Peng, Y. Zhang, S-M. Lui, L. Tartaglia, and R.L. Leibel. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:994-996, 1996.
  3. Chung, W.K., L. Power-Kehoe, M. Chua, R.L. Leibel. Mapping of the OB receptor (OBR) to 1p in a region of non-conserved gene order from mouse and rat to human. Genome Research. 6:431-438, 1996.
  4. Chua, S.C., D.W. White, L. Power-Kehoe, X. S. Wu-Peng, S-M. Liu, N. Okada, Et al. &, R.L. Leibel. Phenotype of fatty due to Gln269Pro mutation in the Leptin Receptor (LEPR). Diabetes. 45:1141-1143, 1996.
  5. Rosenbaum, M., M. Nicolson, J. Hirsch, S.B. Heymsfield, D. Gallagher, and R.L. Leibel. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab. 81(9):3424-3427, 1996.
  6. Leibel, R.L. And finally, genes for human obesity. Nature Genetics. 16:218-220, 1997.
  7. Leibel, R.L., W.K. Chung and S.C. Chua, Jr. The molecular genetics of rodent single gene obesities. J. Biol. Chem. 272:31937-31940, 1997.
  8. Wu-Peng, X.S., S. C. Chua, Jr., N. Okada, S-M. Liu, M. Nicolson, and R. L. Leibel. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the Leptin receptor (LEPR): evidence for deficient plasma - to - CSF transport of Leptin in both the Zucker and Koletsky obese rat. Diabetes. 46:513-518. 1997.
  9. Chung, W.K., M. Zheng, M. Chua, E. Kershaw, L. Power-Kehoe, I. Tsuji, X.S. Wu-Peng, J. Williams, S.C.
  10. Chua, and R.L. Leibel. Genetic modifiers of LEPRfa which alter susceptibility to NIDDM. Genomics. 41:332-244. 1997.
  11. Chung, W.K., L. Power-Kehoe, M. Chua, F. Chu, L. Aronne, Z. Huma, ET AL., and R.L. Leibel. Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes. 46:1509-1511. 1997.
  12. Rosenbaum, M., M. Nicolson, J. Hirsch, E. Murphy, and R.L. Leibel. Effects of weight change on plasma leptin concentrations and energy expenditure. J. Clin Endoc.Metab. 82:3647-3654, 1997.
  13. Silver K, Walston, Chung W.K., Yao F., Parikh V.V., Andersen, Cheskin L.J., Elahi D., Muller D, Leibel R.L., and A.R. Shuldiner. The GLN223ARG and LYS656ASN Polymorphisms in the human leptin receptor do not associate with traits related to NIDDM or obesity. Diabetes. 46:1898, 1997.
  14. Zhang, Y., M. Olbort, K. Schwarzer, M. Nicholson, E. Murphy, et. al and R.L. Leibel. The leptin receptor mediates apparent autocrine regulation of leptin receptor gene. Biochem Biol Res Commun, 240:492-495, 1997. C
  15. hung, W.K., K. Belfi, M. Chua, J. Wiley, R. Mackintosh, M. Nicolson, and R. L. Leibel. Heterozygosity for Lepob and LEPRdb affects body composition and leptin homeostasis in adult mice. Am. J. Physiol. 274:R985-990, 1998.
  16. Rosenbaum M. and R.L. Leibel. The role of leptin in human physiology. New Engl J Med 341:913-915, 1999.
  17. Chung, W.K., A. Luke, R.S. Cooper, C. Rotini, A. Vidal-Puig, M. Rosenbaum, M. Chua and R. L. Leibel. Genetic and Physiological Analysis of the Role of UCP3 in Energy Homeostasis, Diabetes 48:1890-1895, 1999.
  18. Lee M.S., M.P. Wajnrajch, S.S. Kim, L.P. Plotnick, J. Wang, J.M. Gertner, R.L. Leibel, P.S. Dannies. Autosomal dominant growth hormone (GH) deficiency type II: the Del32-71-GH deletion mutant suppresses secretion of wild-type GH. Endocrinology. 141:883-890, 2000.
  19. Leibel, R.L., S.C. Chua and M. Rosenbaum. Obesity: The Molecular Physiology of Weight Regulation in The Metabol Basis of Inherited Disease, VIII Edition, C.R. Scriver, A.L. Beaudet, W.S. Sly and D. Valle, Editors, 2001. pp. 3965- 4028.
  20. Kowalski, T.J., Liu, S-M, Leibel, R.L., Chua, S.C. Transgenic complementation of Leptin Receptor Deficiency- Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes. 50:425-435, 2001.
  21. Heo, M., Leibel, R.L., Boyer, B.B., Chung, W.K., Koulu, M, et al. Pooling Analysis of Genetic Data: The Association of Leptin Receptor (LEPR) Polymorphisms with Variables Related to Human Adiposity. Genetics. 159:1163-1178, 2001.
  22. Ferrante, A, Jr., Thearle, M., Liao, T., Leibel, R.L. Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Diabetes. 50:2268-2278, 2001.
  23. Zhang, Y., Guo, K-Y., Diaz, P.A., Heo, M., Leibel, R.L. Determinants of leptin gene expression in fat depots of lean mice. Am. J. Physiol. Reg. Integrative Comp. Physiol. 282:R226-R234, 2002.
  24. Rosenbaum, M., Murphy, E, Heymsfield, SB, Matthews, DE and Leibel, RL. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab. 87:2391-4. 2002
  25. Yong-Chuan T. and Leibel R.L. Identifying functional relationships among human genes by systematic analysis of biological literature. BMC Bioinformatics, 3:16, 2002.
  26. Phan, L.K. Feng, L. LeDuc, C.A., Chung, W.K., and Leibel, R.L. The mouse mahoganoid (md) coat color mutation disrupts a novel C3HC4 Ring domain protein. J. Clin Invest. 110:1449-1460, 2002.
  27. Rosenbaum, M., K. Vaenborne, J. Leigh, R. Goldsmith, J.A. Simoneau, J. Hirsch, K. Segal, R.L. Leibel. Effects of weight perturbation on skeletal muscle work efficiency & fuel utilization. Am. J. Physiol.. 285:R183-92. 2003.
  28. Wajnrajch MP, Gertner JM, Sokoloff AS, Ten I, Harbison MD, Netchine I, Maheshwari HG, Goldstein DB, Amselem S, Baumann G, Leibel RL. Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the Indian subcontinent with the identical mutation in the GHRH receptor. Am. J. Medical Genetics, 120A(1): 77-83; 2003.
  29. Korner J, Leibel RL. To eat or not to eat - how the gut talks to the brain. N Engl J Med. 349: 926-8. 2003
  30. Weisberg, S.P., McCann, D., Desai, M., Rosenbaum, M., Leibel, RL, and Ferrante, A. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112:1796-1803. 2003.
  31. Guo, K-Y, Halo, P., Leibel, RL and Zhang, Y. Effects of obesity on the relationship of leptin on mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am. J. Physiol. Reg. Integrative Comp. Physiol. 287:R112-9. 2004.
  32. Seidelmann SB, De Luca C, Leibel RL, Breslow JL, Tall AR, Welch CL. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol. 25:204-210. 2005

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