Mousumi Bose, Ph.D.

EDUCATION

2007Ph.D., Department of Nutritional Sciences Rutgers, The State University of New Jersey New Brunswick, NJ
1999B.S., Physiology/Neurobiology University of Maryland College Park, MD

PROFESSIONAL EXPERIENCE

2007 - presentPostdoctoral Fellow, New York Obesity Research Center, Department of Medicine, St. Luke's Roosevelt Hospital Center, New York, NY
Mentor: Blandine Laferr¨¨re, M.D.
Project: Gastrointestinal hormones after weight loss surgery
2003 - 2007Graduate Fellow, Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ
Mentor: C.S. Yang, Ph.D.
Projects:
  • Effect of epigallocatechin-gallate on the development of obesity and diabetes in a rodent model
  • Effect of epigallocatechin-gallate and omega-3 polyunsaturated fatty acids in colon cancer prevention in a transgenic rodent model
1999 - 2002Laboratory Research Technician, Radiation Oncology, University of Maryland, Baltimore, MD
Supervisor: William F. Morgan, Ph.D.
Projects:
  • Intensity-modulated radiation therapy vs. conventional radiotherapy in an in vitro model
  • The protective effect of sphingosine 1-phosphate on genomic stability in offspring of irradiated mice
  • The effects of low doses of ionizing radiation on genomic instability in the transgenic heterozygous Nbs1 mouse
1998 - 1999Undergraduate Research Assistant, Diving Physiology, Naval Medical Research Institute, Bethesda, MD
Supervisor: Suzan Nadi, Ph.D.
Project: The role of Neuropeptide Y in epileptic and hypoxia-induced seizures

PUBLICATIONS

Research Articles

  1. Bose M, Lambert JD, Ju J, Reuhl KR, Shapses SA, Yang CS. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat fed mice. J Nutr, 2008; 138(9):1677-83.
  2. Ju J, Nolan B, Cheh M, Bose M, Lin Y, Wagner GC, Yang CS. Voluntary exercise inhibits intestinal tumorigenesis in ApcMin/+ mice and azoxymethane/dextran sulfate sodium-treated mice. BMC Cancer, 2008; 8(1):316.
  3. Lambert JD, Kwon SJ, Ju J, Bose M, Lee MJ, Hong J, Hao X, Yang CS. Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate. Carcinogenesis. 2008 ;29(10):2019-24.
  4. Bose M, Hao X, Ju J, Husain A, Park S, Lambert JD, Yang CS. Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. J Agri Food Chem, 2007; 55 (19): 7695-7700.
  5. Hao X*, Bose M*, Lambert JD, Ju J, Lee M-J, Park S, Husain A, Wang S, Sun Y, Yang CS. Inhibition of Tumorigenesis in ApcMin/+ Mice by Green Tea Polyphenols (Polyphenon E) and Individual Catechins. Nutr Cancer, 2008; 59(1): 62-69. *Both authors contributed equally to this manuscript
  6. Sang S, Ju J, Lambert JD, Lin Y, Hong J, Bose M, Wang S, Bai N, He K, Reddy BS, Ho CT, Li F, Yang CS. Wheat Bran Oil and Its Fractions Inhibit Human Colon Cancer Cell Growth and Intestinal Tumorigenesis in Apc(min/+) Mice. J Agric Food Chem. 2006;54(26):9792-9797.
  7. Lambert JD, Lee MJ, Diamond L, Ju J, Hong J, Bose M, Newmark HL, Yang CS. Dose-dependent Levels of Epigallocatechin-3-gallate in Human Colon Cancer Cells and Mouse Plasma and Tissues. Drug Metabol. Disp. 2006; 34(1):8-11.
  8. Ju J, Hong J, Zhou, J-N, Pan Z, Bose M, Liao J, Yang G-Y, Liu Y-Y, Hou Z, Lin Y, Ma J, Shih WJ, Carothers AM, Yang CS. Inhibition of intestinal tumorigenesis in ApcMin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res. 2005; 65(22): 10623-31.
  9. Hong J, Bose M, Ju J, Ryu JH, Chen X, Sang S, Lee MJ, Yang CS. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 2004 Sep;25(9):1671-9.
  10. Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick R. Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med 2002 Nov;8(11):1329.

Reviews

Abstracts and Presentations

  1. Bose M, Oliv¨˘n B, Teixeira JA, McGinty JJ, Colarusso A, Kovacs BL, Bawa B, Chang T, Summe HS, Laferr¨¨re B. Changes of ghrelin levels after weight loss: is bariatric surgery different than diet? Oral presentation at The Obesity Society 2008 Annual Meeting. Obesity 2008; 16, Supp1, OR 27, S54.
  2. Bose M, Oliv¨˘n B, Teixeira JA, McGinty JJ, Colarusso A, Kovacs BL, Bawa B, Summe HS, Chang T, Laferr¨¨re B. Gastric bypass surgery improves post-prandial glucose and increases incretin levels more than diet-induced weight loss in patients with type 2 diabetes. Poster presentation at the 2008 American Diabetes Association Annual Scientific Meeting.
  3. Bose M, Hao X, Ju J, Husain A, Park S, Yang CS. Inhibition of intestinal tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil or calcium. Poster presentation at the 2006
  4. American Association for Cancer Research Annual Meeting and at the 2006 Cancer Institute of New Jersey Annual Retreat.
  5. Bose M, Ju J, Husain A, Park S, Hou Z, Lambert JD, Newmark HL, Yang CS. Inhibition of tumor multiplicity in ApcMin/+ mice by supplementation of 10 vitamins and minerals. Poster presentation at the 2005 Cancer Institute of New Jersey Annual Retreat.

HONORS AND MEMBERSHIPS

2008-2010National Institute of Health Loan Repayment Program Contract for proposal entitled Mechanisms of Diabetes Control After Bariatric Surgery
2008Travel Grant for participation in The Obesity Society 2008 Annual Meeting
2008Member, The Obesity Society
2007Travel Award for participation in the scientific poster session at Fourth International Scientific Symposium on Tea & Human Health
2007Scientific Poster Session 3rd Place Award for poster entitled The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat fed mice. Presented at the Fourth International Scientific Symposium on Tea & Human Health
2005-2007Pre-doctoral Fellowship Award for proposal entitled EGCG and omega-3 PUFA in Colon Cancer Prevention. Awarded by New Jersey Commission for Cancer Research
2007Science Communication Award-Graduate Division for research poster entitled Inhibition of obesity and related pathologies by (-)-epigallocatechin-3-gallate (EGCG) in high-fat fed mice. Presented at the 14th Annual Rutgers' Cook College and New Jersey Agricultural Experiment Station Awards Dinner
2006New Jersey Cancer Research Award for Scientific Excellence for abstract entitled Inhibition of intestinal tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil or calcium. Awarded by New Jersey Commission for Cancer Research at the 2006 Cancer Institute of New Jersey Annual Retreat
2006Science Communication Award-Graduate Division for research poster entitled Inhibition of intestinal tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil or calcium. Presented at the 13th Annual Rutgers' Cook College and New Jersey Agricultural Experiment Station Awards Dinner
2005New Jersey Cancer Research Award for Scientific Excellence for abstract entitled Inhibition of tumor multiplicity in ApcMin/+ mice by supplementation of 10 vitamins and minerals. Awarded by New Jersey Commission for Cancer Research at the 2005 Cancer Institute of New Jersey Annual Retreat
1995-1996Honors Program, University of Maryland at College Park

RESEARCH SUPPORT

2007 - presentRuth L. Kirschstein National Research Service Award Training Grant T32 DK07559
Role: Postdoctoral Trainee under Blandine Laferr¨¨re, M.D.
2005-2007New Jersey Commission for Cancer Research Pre-doctoral Fellowship Award
Role: Pre-doctoral Trainee under C.S. Yang, Ph.D.

TEACHING EXPERIENCE AND GUEST LECTURES

2006 - 2007Dietary factors in cardiovascular disease. Invited guest lecture for Nutrition and Disease course for pharmacy students. Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey
2003Teaching Assistant, Biology 102, Department of Biology, Rutgers, The State University of New Jersey
Duties: Responsible for management of 2 laboratory sections of 2nd semester introductory undergraduate biology course
2002Teaching Assistant, Biology 101, Department of Biology, Rutgers, The State University of New Jersey
Duties: Responsible for management of 2 laboratory sections of 1st semester introductory undergraduate biology course


OBESITY RESEARCH CENTER