The New York Obesity Nutrition Research Center


Peer Reviewed

(Jan 2006 – Dec 2006)

1.   Buteau J, Spatz ML, Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes. 2006;55(5):1190-6. (Core: AT and MBMG)

2.   Chung WK, Leibel RL. The links between obesity, leptin, and prostate cancer. Cancer J 2006; 12(3):178-181. (Core: MBMG, HM)

3.   Codner, E., Deng, L., Pérez-Bravo, F., Román, R., Lanzano, P., Cassorla, F.,and  Chung, W.K., Glucokinase mutations in young children with hyperglycemia.  Diabetes and Metabolism Research and Reviews. 2006. 22(5):348-55. (Core: MBMG, HM)

4.   Collins SJ, Alexander SL, Lopez-Guisa JM, Cai X, Maruvada R, Chua SC, Zhang G, Okamura DM, Matsuo S, Eddy AA. Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. Nephron Exp Nephrol. 2006;104(1):e23-34. (Core: MBMG)

5.   Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab. 2006;4(4):291-302. (Core: MBMG)

6.   Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Jr., Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49(2):191-203. (Core: AT, MBMG)

7.   Han S, Liang CP, DeVries-Seimon T, Ranalletta M, Welch CL, Collins-Fletcher K, Accili D, Tabas I, Tall AR. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab. 2006;3(4):257-66. (Core: AT, MBMG)

8.   Kishore PTonelli JKoppaka SFratila CBose ALee DEReddy KHawkins M. Time-dependent effects of free fatty acids on glucose effectiveness in type 2 diabetes. Diabetes 2006; 55(6):1761-1768. (Core: MBMG and HM)

9.   Kitamura T, Feng Y, Kitamura YI, Chua SC, Jr., Xu AW, Barsh GS, Rossetti L, Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006;12(5):534-40. (Core: MBMG,IB, AEP, AT and HM)

10. Luo N, Liu SM, Liu H, Li Q, Xu Q, Sun X, Davis B, Li J, Chua S, Jr. Allelic variation on chromosome 5 controls beta-cell mass expansion during hyperglycemia in leptin receptor-deficient diabetes mice. Endocrinology. 2006;147(5):2287-95. (Core: MBMG)

11. Matsumoto M, Han S, Kitamura T, Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest. 2006;116(9):2464-72. PMCID: 1533874. (Core: AT and MBMG)

12. Matsuoka N, Patki A, Tiwari HK, Allison DB, Johnson SB, Gregersen PK, Leibel RL, Chung WK. Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults. Int J Obes (Lond). 2006;30(2):233-7. (Core: MBMG)

13. Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D. Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J Clin Invest. 2006;116(3):775-82. PMCID: PMC1370178. (Core: AT and MBMG)

14. Phan LK, Chung WK, Leibel RL. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 2006; 291(3):E611-E620. (Core: MBMG, HM and AT)

15. Qi Y, Nie Z, Lee YS, Singhal NS, Scherer PE, Lazar MA, Ahima RS. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 2006; 55(11):3083-3090. (Core: MBMG and HM)

16. Souza F, Simpson N, Raffo A, Saxena C, Maffei A, Hardy M, Kilbourn M, Goland R, Leibel R, Mann JJ, Van Heertum R, Harris PE. Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest. 2006;116(6):1506-13. PMCID: 1462946. (Core: MBMG)

17. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006; 116(1):115-124. (Core: IB, AEP, MBMG and HM)

(Jan 2007 – Dec, 2007)

18. Adachi M, Osawa Y, Uchinami H , Kitamura T, Accili D, Brenner DA. The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells. Gastroenterology 2007. 132:1434-1446. PMID: 17408630. (Core: HM and MBMG)

19. Buteau J, Shlien A, Foisy S, Accili D. Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1. J Biol Chem. 2007;282(1):287-93. (Core: AT, MBMG and HM)

20. Freda PU, Chung WK, Matsuoka N, Walsh N, Walsh JE, Kanibir MN, Kleinman G, Wang Y, Bruce JN, Post KD. Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-I criteria for remission. Pituitary. 2007; 10(3): 275-82. PMID: 17594522. (Core: HM and MBMG)

21. Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L, Loh D, Li C, Chua S, Jr., Zhang Y. Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities. Endocrinology. 2007; 148:3987-3997. (Core: AT and MBMG)

22. Johnson JA, Trasino SE, Ferrante AW, Jr., Vasselli JR. Prolonged Decrease of Adipocyte Size after Rosiglitazone Treatment in High- and Low-Fat-Fed Rats. Obesity (Silver Spring). 2007; 15:2653-2663. (Core: AT, MBMG and HM)

23. Karnib HH, Chua S, Gharavi AG. Genes for diabetic nephropathy: sweet prospects on the horizon. Kidney Int. 2007;71(2):94-6. (Core: MBMG)

24. Kim JJ, Kido Y, Scherer PE, White MF, and Accili D. Analysis of compensatory beta cell response in mice with combined mutations of Insulin Receptor and Irs2. Am J Physiol Endocrinol Metab. 2007. 292(6): E1694-1701. PMID: 17299086. (Core: HM and MBMG)

25. Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest. 2007;117(9):2477-85. PMCID: 1950461. (Core: AT, MBMG and HM)

26. Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R. Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring). 2007;15(5):1061-7. (Core: MBMG)

27. Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R. Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care. 2007;30(6):1647-52. (Core: MBMG)

28. Lee M, Kim A, Chua SC, Jr., Obici S, Wardlaw SL. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab. 2007;293(1):E121-31. (Core: AT and MBMG)

29. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456-69. PMCID: 2013746. (Core: AT and MBMG)

30. Lin HV, Kim JY, Pocai A, Rossetti L, Shapiro L, Scherer PE, and Accili D. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic knockout mice. Diabetes 2007. 56:1969-1976. PMID: 17475934. (Core: HM, MBMG, and AT)

31. Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007;6(3):208-16. (Core: AT, MBMG and HM)

32. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Eagle AR, Vats D, Brombacher F, Ferrante AW, Chawla A. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007; 447:1116-1120. PMCID:PMC2587297 (Core: AT, MBMG and HM)

33. Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest. 2007;117(2):397-406. PMCID: 1765516 Core (Chua)  acknowledged for generation of promoter/enhancer (Core: MBMG)

34. Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimaki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M. Strong association of de novo copy number mutations with autism. Science. 2007;316(5823):445-9. (Core: MBMG)

35. Shawber, CJ, Funahashi, Y, Francisco, E, Vorontchikhina, M, Kitamura, Y, Stowell, SA, Borisenko, V, Feirt, N, Podgrabinska, S, Shiraishi,K,  Chawengsaksophak, K., Rossant, J , Accili, D, Skobe, M, and Kitajewski, J. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin. Invest. 2007.117: 3369-3382. PMID: 17948123. (Core: HM and MBMG)

36. Sun, HD, Malabunga, M, Tonra, JR, DiRenzo, R, Carrick, FE, Zheng, H, Berthoud, HR, McGuinness, OP, Shen, J, Bohlen, P, Leibel, RL, Kussie, P. Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab. 2007; 292:E964-76. (Core: HM and MBMG)

37. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH.  Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes. 2007 Jun;56(6):1647-54. Epub 2007 Mar 14.PMID: 17360978 (Core: AEP, AT and MBMG)

(Jan 2008 – Dec, 2008)

38. Banks AS, Kon N, Knight C, Matsumoto M, Gutierrez-Juarez R, Rossetti L, Gu W, Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008; 8:333-341. (Core: AT, MBMG and HM)

39. Blouet C, Ono H, Schwartz GJ.  Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab. 2008 Dec;8(6):459-67. PMCID: PMC2637401  (Core: AEP and MB/MG)

40. Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons. Science. 2008 Jul 31. 29;321 (5893):1218-1221, 2008. PMID: 18669821. (Core: HM and MBMG)

41. Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B, Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK, Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008;4(7):e1000137. PMCID: 2464733. (Core: AT, MBMG and HM)

42. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A. 2008;105(13):5266-70. PMCID: 2278202. (Core: AT and MBMG)

43. Freeby M, Goland R, Ichise M, Maffei A, Leibel R, Harris P. VMAT2 quantitation by PET as a biomarker  for beta-cell mass in health and disease. Diabetes Obes Metab. 2008;10 Suppl 4:98-108. (Core: MBMG)

44. Harris RB, Leibel RL. Location, location, location. Cell Metab. 2008;7(5):359-61. (Core: MBMG)

45. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG, Jr., Chua SC, Jr., Kim JK, Kaestner KH, Karsenty G. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol. 2008;183(7):1235-42. PMCID: 2606962. (Core: MBMG)

46. Kim KW, Jo YH, Zhao L, Stallings NR, Chua SC, Jr., Parker KL. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol. 2008;22(8):1950-61. PMCID: 2505330. (Core: MBMG)

47. Korner J, Punyanitya M, Taveras C, McMahon DJ, Kim HJ, Inabnet W, Bessler M, Gallagher D. Sex differences in visceral adipose tissue post-bariatric surgery compared to matched non-surgical controls.  Int J of Body Composition Res. 2008;6:93-9. (Core: AT and MBMG)

48. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW, Jr., Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008; 8:468-481. PMCID:PMC2746325 (Core: AT, HM and MBMG)

49. Murthy R, Harris P, Simpson N, Van Heertum R, Leibel R, Mann JJ, Parsey R. Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates. Eur J Nucl Med Mol Imaging. 2008;35(4):790-7. (Core: MBMG)

50. Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 2008; 7:496-507. PMCID:PMC2587370 (Core: AT, AP, MBMG and HM)

51. Raffo, A, Hancock K, Polito T, Xie Y, Andan G, WItkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE. Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol. 2008 Jul;198(1):41-9. PMCID: PMC2712213. (Core: HM and MBMG)

52. Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WSGoldberg IJ, Schwabe RF, Chua SC Jr., Huang L-S. Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids and Ameliorates Steatosis. J Biol Chem, 57:1674-82, 2008. PMCID: PMC2442319. (Core: HM and MBMG)

53. Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr. 2008 Oct;88(4):906-12. (Core: HM and MBMG)

54. Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest. 2008 Jul;118(7):2583-91. PMCID: PMC2430499. (Core: HM and MBMG)

55. Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes. 2008;57(11):2967-76. PMCID: 2570393. (Core: AT and MBMG)

56. Shi H, Strader AD, Sorrell JE, Chambers JB, Woods SC, Seeley RJ. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab. 2008;294(3):E630-9. (mice provided by core (Chua), acknowledged in paper) (Core: MBMG)

57. Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol. 2008; 294:R1185-1196. PMCID:PMC2808712 (Core: AT and MBMG)

58. van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.  Endocrinology. 2008 Apr;149(4):1773-85.  PMCID: PMC2276717  (Core: AEP, MB/MG and HM)

59. Wardle J, Carnell S, Haworth CMA, Farooqi IS, O’Rahilly S & Plomin, R. Obesity-associated variation in FTO is associated with diminished satiety in children. Journal of Clinical Endocrinology & Metabolism 2008; 93, 3640-3643. (Core: MBMG)

60. Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology. 2008; 149:3549-3558. PMCID:PMC2453081 (Core: AT and MBMG)

(Jan 2009 – Dec, 2009)

61. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009;284(45):31236-48. PMCID: PMC2781522. (Core: MBMG)

62. Anderson KR, White P, Kaestner KH, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009;9:65. PMCID: PMC2799404. (Core: MBMG)

63. Blouet C, Jo YH, Li X, Schwartz GJ. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.  J Neurosci. 2009 Jul 1;29(26):8302-11. PMCID: PMC2740923  (Core: AEP and MB/MG)

64. Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J. 2009;23(9):3059-69. PMCID: 2735358. (Core: MBMG)

65. Chang W, Winder TL, LeDuc CA, Simpson LL, Millar WS, Dungan J, Ginsberg N, Plaga S, Moore SA, Chung WK. Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families. Prenat Diagn. 2009;29(6):560-9. PMCID: 2735827. (Core: MBMG)

66. Chung WK, Patki A, Matsuoka N, Boyer BB, Liu N, Musani SK, Goropashnaya AV, Tan PL, Katsanis N, Johnson SB, Gregersen PK, Allison DB, Leibel RL, Tiwari HK. Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Hum Hered. 2009;67(3):193-205. PMCID: 2715950. (Core: MBMG)

67. Chung WK, Shin M, Jaramillo TC, Leibel RL, LeDuc CA, Fischer SG, Tzilianos E, Gheith AA, Lewis AS, Chetkovich DM. Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis. 2009;33(3):499-508. PMCID: 2643333. (Core: MBMG)

68. Codner E, Rocha A, Deng L, Martinez-Aguayo A, Godoy C, Mericq V, Chung WK. Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus. Pediatr Diabetes. 2009;10(6):382-8. (Core: MBMG)

69. Guo K, Mogen J, Struzzi S, Zhang Y. Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol. 2009; 296:R1339-1347. PMCID:PMC2689822 (Core: AT and MBMG)

70. Han S, Liang CP, Westerterp M, Senokuchi T, Welch CL, Wang Q, Matsumoto M, Accili D, Tall AR. Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest. 2009;119(4):1029-41. PMCID: 2662550 (Core: AT and MBMG)

71. Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, Sun Y, Smith RG, Sussel L. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept. 2009;157(1-3):51-6. PMCID: PMC2828774. (Core: MBMG)

72. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Kajimura D, Myers MG, Jr., Chua SC, Jr., Wang Q, Kim JK, Kaestner KH, Karsenty G. An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci. 2009;1173 Suppl 1:E20-30. (Core: MBMG)

73. Jo YH, Chua S, Jr. Transcription factors in the development of medial hypothalamic structures. Am J Physiol Endocrinol Metab. 2009;297(3):E563-7. PMCID: 2739694. (Core: MBMG)

74. Jo YH, Su Y, Gutierrez-Juarez R, Chua S Jr . Oleic acid directly regulates POMC neuron excitability in the hypothalamus.. J Neurophysiol. 2009 May;101(5):2305-16. PMCID: PMC2681442 (Core: AEP and MB/MG)

75. Khan T, Hamilton MP, Mundy DI, Chua SC, Scherer PE. Impact of simvastatin on adipose tissue: pleiotropic effects in vivo. Endocrinology. 2009;150(12):5262-72. PMCID: 2795715. (Core: MBMG)

76. Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol. 2009; 29:1575-1591. PMCID:PMC2648231 (Core: AT and MBMG)

77. Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol Cell Biol. 2009;29(16):4417-30. PMCID: 2725741. (Core: MBMG)

78. Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S, Jr., Diano S, Horvath TL, Seeley RJ, Becker JB, Munzberg H, Myers MG, Jr. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab. 2009;10(2):89-98. PMCID: 2723060. (Core: MBMG)

79. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A. 2009;106(37):15768-73. PMCID: 2735559. (Core: MBMG)

80. Nagajyothi F, Desruisseaux MS, Jelicks LA, Machado FS, Chua S, Scherer PE, Tanowitz HB. Perspectives on adipose tissue, chagas disease and implications for the metabolic syndrome. Interdiscip Perspect Infect Dis. 2009;2009:824324. PMCID: 2715900. (Core: MBMG)

81. Nagajyothi F, Desruisseaux MS, Weiss LM, Chua S, Albanese C, Machado FS, Esper L, Lisanti MP, Teixeira MM, Scherer PE, Tanowitz HB. Chagas disease, adipose tissue and the metabolic syndrome. Mem Inst Oswaldo Cruz. 2009;104 Suppl 1:219-25. (Core: MBMG)

82. Ortega Martinez de Victoria E, Xu X, Koska J, Francisco AM, Scalise M, Ferrante AW, Jr., Krakoff J. Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians. Diabetes. 2009; 58:385-393. PMCID:PMC2628612 (Core: AT, MBMG and HM)

83. Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med. 2009;15(10):1195-201. PMCID: 2777744. (Core: AT, MBMG, and HM)

84. Stratigopoulos G, LeDuc CA, Matsuoka N, Gutman R, Rausch R, Robertson SA, Myers MG, Jr., Chung WK, Chua SC, Jr., Leibel RL. Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring). 2009;17(1):126-35. PMCID: 2808713. (Core: AT, MBMG, and HM)

85. Talchai C, Lin HV, Kitamura T, Accili D. Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabetes Obes Metab. 2009;11 Suppl 4:38-45. (Core: MBMG)

86. Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D. Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes. 2009;58(10):2344-54. PMCID: 2750207. (Core: MBMG)

87. Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009;138(5):976-89. PMCID: 2768582. (Core: MBMG)

(Jan 2010 – May, 2010)

88. Chua S, Li Y, Liu S, Liu R, Chan K, Martino J, Zheng Z, Susztak K, D'Agati V, Gharavi A. Mapping a Susceptibility Gene for Diabetic Nephropathy to Mouse Chromosome 8 in db/db FVB/NJ, an Obese Model of Type II Diabetes. Kidney International. 2010;In press. (Core: MBMG)

89. Goldsmith R, Joanisse DR, Gallagher D, Pavlovich K, Shamoon E, Leibel RL, Rosenbaum M. Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol. 2010;298(1):R79-88. PMCID: 2806213. (Core: AT, BC, MBMG, and HM)

90. Gu C, Stein GH, Pan N, Goebbels S, Hornberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab. 2010;11(4):298-310. PMCID: PMC2855640. (Core: MBMG)

91. Halldorsdottir S, Carmody J, Boozer C, LeDuc C, Leibel R. Reproducibility and Accuracy of Body Composition Assessments in Mice by Dual Energy X-ray Absorptiometry and Time Domain Nuclear Magnetic Resonance. International Journal of Body Composition Research. 2010;In Press. (Core: AT and MBMG)

92. He J, Le DS, Xu X, Scalise M, Ferrante AW, Krakoff J. Circulating white blood cell count and measures of adipose tissue inflammation predict higher 24-h energy expenditure. Eur J Endocrinol. 2010; 162:275-280. (Core: AT and MBMG)

93. Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L. Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol Endocrinol. 2010;24(2):381-90. PMCID: PMC2817598. (Core: MBMG)

94. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Bruning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010;11(4):286-97. PMCID: 2854520. (Core: MBMG)

95. Iqbal J, Li X, Chang BH, Chan L, Schwartz GJ, Chua SC Jr, Hussain MM. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption.  J Lipid Res. 2010 Jul;51(7):1929-42. PMID: 20164094 (Core: AEP and MB/MG)

96. Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S, Jr., Itoh H, Noda T, Kasuga M, Nakae J. PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab. 2010;298(4):E787-98 (Core: MBMG)

97. Israel D, Chua S, Jr. Leptin receptor modulation of adiposity and fertility. Trends Endocrinol Metab. 2010;21(1):10-6. PMCID: 2818174. (Core: MBMG)

98. Keller KL, Reid A, MacDougall M, Cassano H, Song JL, Deng L, Lanzano P, Chung W, Kissileff HR.  Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6 year-old children.  Obesity 2010 Jun;18(6):1194-200 PMCID: PMC2877149. (Core: BS, MBMG, BC and IB)

99. Kinnally EL, Capitanio JP, Leibel R, Deng L, Leduc C, Haghighi F, Mann JJ. Epigenetic Regulation of Serotonin Transporter Expression and Behavior in Infant Rhesus Macaques. Genes Brain Behav. 2010. (Core: MBMG)

100.       Lin HV, Plum L, Ono H, Gutierrez-Juarez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes. 2010;59(2):337-46. PMCID: PMC2809966. (Core: AT and MBMG)

101.       Nagajyothi, F, Zhao, S.  Machado, F.S., Weiss L.M., Schwartz, G.J., Desruisseaux ,M.S.,   Zhao Y. Factor S.M., Huang  H., Albanese C., Mauro M., Teixeira J., Scherer , P.E., Chua Jr. S.C., Tanowitz, H.B. Trypanosoma cruzi infection in diabetic mice: role of the leptin receptor, Journal of Infections Diseases, in press. (Core: AEP and MB/MG)

102.       Obstfeld AE, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, Ables EV, Ferrante AW, Jr. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes. 2010; 59:916-925. PMCID:PMC2844839 (Core: AT, MBMG and HM)

103.       Padilla SL, Carmody JS, Zeltser LM. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med. 2010;16(4):403-5. PMCID: 2854504. (Core: MBMG)

104.       Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ. The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis. Physiol Behav. 2010;100(2):165-72. (mice provided by core (Chua), acknowledged in paper) (Core: MBMG)

105.       Tabas I, Tall A, Accili D. The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res. 2010;106(1):58-67. PMCID: 2805467. (Core: MBMG)

106.       Tschop J, Nogueiras R, Haas-Lockie S, Kasten KR, Castaneda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S, Jr., Farooqi IS, O'Rahilly S, Caldwell CC, Tschop MH. CNS leptin action modulates immune response and survival in sepsis. J Neurosci. 2010;30(17):6036-47. PMCID: 2868384. (Core: MBMG)

107.       Zaghloul N, Liu Y, Gerdes J, Gascue C, Oh E, Leitch C, Bromberg Y, Binkley J, Leibel R, Sidow A, Badano J, Katsanis N. Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome PNAS. 2010;in press. (Core: MBMG)

Review Articles

(Jan 2006 – Dec 2006)

1.   Chung WK, Leibel RL. The links between obesity, leptin, and prostate cancer. Cancer J. 2006;12(3):178-81. (Core: MBMG)

2.   Leibel RL. The molecular genetics of the melanocortin pathway and energy homeostasis. Cell Metab. 2006;3(2):79-81 (Core: AT and MBMG)

3.   M. Matsumoto and D. Accili (2006). The tangled path to glucose production. Nat. Med. 12: 33-34. (Core: MBMG)

(Jan 2007 – Dec 2007)

4.   Hsing AW, Sakoda LC, Chua S Jr. Obesity, metabolic syndrome, and prostate cancer. Am J Clin Nutr. 2007 Sep;86(3):s843-57. Review. PubMed PMID: 18265478. (Core: MBMG)

5.   Tabas I, Seimon T, Arellano J, Li Y, Forcheron F, Cui D, Han S, Liang CP, Tall A, Accili D. The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis. Novartis Found Symp. 2007;286:99-109; discussion -12, 62-3, 96-203. PMCID: 2613853. (Core: MBMG)

(Jan 2008 – Dec 2008)

6.   D. Leroith and D. Accili (2008). Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nat. Clin. Pract. Endocrinol. Metab. 4:164-172. PMC2714226 (Core: MBMG)

7.   Chung, WK  and Leibel, RL.  Considerations regarding the genetics of obesity. Obesity. 2008:16 3:S33-9  PMCID: PMC2682366. (Core: HM and MBMG)

8.   Freeby M, Goland R, Ichise M, Maffei A, Leibel R, Harris P. VMAT2 quantitation by PET as a biomarker for beta-cell mass in health and disease.  Diabetes Obes Metab. 2008;10 Suppl 4:98-108. (Core: MBMG)

9.   I.D. Goldfine, B.A. Maddux, J.F. Youngren, G. Reaven, D. Accili, V. Trischitta, R. Vigneri, L. Frittitta (2008). The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr. Rev. 29:62-75. PMC2244935 (Core: MBMG)

10. Haeusler, R.A. and Accili, D. (2008). The double life of Irs. Cell Metab. 8: 7-9. PMC2712626 (Core: MBMG)

11. Leroith, D. and D. Accili (2008). Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nat. Clin. Pract. Endocrinol. Metab. 4:164-172. PMC2714226 (Core: MBMG)

12. Leibel RL. Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond). 2008;32 Suppl 7:S98-108. PMCID: 2682360. (Core: MBMG)

13. Leibel RL. Energy in, energy out, and the effects of obesity-related genes. N Engl J Med. 2008;359(24):2603-4. (Core: AT & MBMG)

14. Weisberg SP, Leibel RL. An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data. Diabetes. 2008;57(1):1-2. (Core: MBMG)

(Jan 2009 – Dec 2009)

15. C. Talchai, H.V. Lin, T. Kitamura, and D. Accili (2009). Genetic and biochemical pathways of beta-cell failure in type 2 diabetes. Diabetes Obes Metab 11 (Suppl 4): 38-45. (Core: MBMG)

16. Israel D, Chua S Jr. Leptin receptor modulation of adiposity and fertility. Trends Endocrinol Metab. 2010 Jan;21(1):10-6. Epub 2009 Oct 23. Review. PMCID: PMC2818174. (Core: MBMG)

17. Jo YH, Chua S Jr. Transcription factors in the development of medial hypothalamic structures. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E563-7. Epub 2009 Apr 21. Review. PMCID: PMC2739694. (Core: MBMG)

(Jan 2010 – May 2010)

18. I. Tabas , A. Tall, D. Accili (2010). The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ. Res. 106: 58-67. (Core: MBMG and AT)

19. G. Marcelin and S Chua Contributions Of Adipocyte Lipid Metabolism To Body Fat Content And Implications For The Treatment Of Obesity Current Opinion in Pharmacology 2010, in press (Core: MBMG)

20. M.G. Myers Jr, C.R. Kahn, D. Accili (2010). Leptin therapy for type 1 diabetes gains traction. Nat. Med. 2010 16: 380. (Core: MBMG)

21. Martin G. Myers, Jr., Rudolph L. Leibel, Randy J. Seeley, and Michael W. Schwartz Obesity and Leptin Resistance: Distinguishing Cause from Effect. Trends in Endocrinology and Metabolism. Submitted. 2010 (Core: MBMG)

22. Rosenbaum, M. and R.L. Leibel. Adaptive thermogenesis in humans, Int. J. Obesity, In Press, 2010. (Core: MBMG)

Book Chapters

(Jan 2007 – Dec 2007)

1.   Chung W, Leibel R: Overview of human monogenic, nonsyndromic, and syndromic obesity. Clement, K., and Sorensen, T., in Genetics of Obesity. Edited by Taylor, Francis, Sept. 2007 p. 157 (Core: MBMG)

2.   Chung, WK, Leibel, RL, "Molecular Physiology of Monogenic and Syndromic Obesities in Humans." Obesity and Energy Metabolism: Research and Clinical Applications. Donohoue, P. ed. New Jersey: Humana Press. Oct. 28, 2007, p. 1. (Core: MBMG)

3.   Leibel, R.   "Understanding Obesity: Genes and Environment in the Determination of Body Weight", in Bouchard, C. (ed.), Obesity: Epidemiology, Etiology, Consequences and Treatment, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at 2007. (Core: MBMG)

(Jan 2008 – Dec 2008)

4.    Chung, W.K.  Clinical Implementation of Genomic Medicine.  Genomic and Personalized Medicine.  Editors: Geoffrey Ginsburg, G. and Willard, H. eds.  New York: Academic Press/Elsevier.  Pp 357-366. 2008. (Core: MBMG)

5.    Chung, W.K. and Leibel, R.L. Overview of human obesity syndromes. Genetics of Obesity: Genomics and Postgenomics.   Clement, K. and  Sorensen, T., eds.  Informa Healthcare. Chapter 5.1, 2008. (Core: MBMG)

6.    Chung, W.K. Leibel, R.L.  Energy and Metabolism and Obesity: Research and Clinical Applications.  Molecular Physiology of Monogenic and Syndromic Obesities in Human.  Donohoue, P. ed.  New Jersey: Humana Press. pp. 1-22.  2008. (Core: MBMG)

7.    Rosenbaum, M. and R.L. Leibel.  American Academy of Pediatrics Nutrition Handbook (6th ed): Obesity. R. Kleinman, ed. American Academy of Pediatrics, Elk Grove Village, IL, pp.733-82, 2008. (Core: MBMG)

(Jan 2010 – May 2010)

8.    Leibel, R.L. and M. Rosenbaum. Metabolic responses to weight perturbation. In, Novel Insights into Adipose Cell Functions, K. Clement et al. (eds.), Research and Perspectives in Endocrine Interactions, Springer-Verlag Berlin Heidelberg. In Press, 2010 (Core: MBMG)

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