The New York Obesity Nutrition Research Center

PUBLICATIONS that used the ANIMAL PHENOTYPING CORE

Peer Reviewed

(Jan 2006 – Dec 2006)

1.   Kitamura T, Feng Y, Kitamura YI, Chua SC, Jr., Xu AW, Barsh GS, Rossetti L, Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006;12(5):534-40. (Core: MGMB, IB, AP, AT and HM)

2.   Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006; 116(1):115-124. (Core: IB, AP, MGMB and HM)

(Jan 2007 – Dec 2007)

3.   Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, Jelicks LA, Mehler MF, Hui DY, Deshaies Y, Shulman GI, Schwartz GJ, Scherer PE.  Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007 Sep;117(9):2621-37. PMCID: PMC1950456 (Core: HM and AP)

4.   Lam TK, Gutierrez-Juarez R, Pocai A, Bhanot S, Tso P, Schwartz GJ, Rossetti L. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med. 2007 Feb;13(2):171-80..PMID: 17273170 (Core: AP and HM)

5.   Todd BJ, Fraley GS, Peck AC, Schwartz GJ, Etgen AM. Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats.  Biol Reprod. 2007 Sep;77(3):492-503. Epub 2007 Jun 13.PMID: 17567960  (Core: AP)

6.   Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH.  Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes. 2007 Jun;56(6):1647-54. Epub 2007 Mar 14.PMID: 17360978 (Core: AP, AT and MBMG)


(Jan 2008 – Dec, 2008)

7.   Blouet C, Ono H, Schwartz GJ.  Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab. 2008 Dec;8(6):459-67. PMCID: PMC2637401  (Core: AP and MB/MG)

8.   Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A, Su K, Cheng B, Li X, Harvey-White J, Schwartz GJ, Kunos G, Rossetti L,  Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms.  Nat Med. 2008 Jun;14(6):667-75.  PMCID: PMC2671848 (Core: AP and HM)

9.   Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 2008; 7:496-507. PMCID:PMC2587370 (Core: AT, AP, MGMB and HM)

10. Ono H, Pocai A, Wang Y, Sakoda H, Asano T, Backer JM, Schwartz GJ, Rossetti L. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest. 2008 Aug;118(8):2959-68. PMCID: PMC2447927  (Core: AP)

11. Pritchard TC, Nedderman EN, Edwards EM, Petticoffer AC, Schwartz GJ, Scott TR. Satiety-responsive neurons in the medial orbitofrontal cortex of the macaque.  Behav Neurosci. 2008 Feb;122(1):174-82. PMID: 18298260 (Core: AP)

12. Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK Hypothalamic protein kinase C regulates glucose production. . Diabetes. 2008 Aug;57(8):2061-5. PMCID: PMC2494694 (Core: AP)

13. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008 Oct;8(4):281-8. PMCID: PMC2572640 (Core: AP)

14. Song CK, Schwartz GJ, Bartness TJ. Anterograde Transneuronal Viral Tract Tracing Reveals Central Sensory Circuits From White Adipose Tissue.  Am J Physiol Regul Integr Comp Physiol. 2008 Dec 24. [Epub ahead of print] PMCID: PMC2665851 (Core: AP)

15. van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.  Endocrinology. 2008 Apr;149(4):1773-85.  PMCID: PMC2276717  (Core: AP, MB/MG and HM)

16. Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK. Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.  Nature. 2008 Apr 24;452(7190):1012-6.  PMID: 18401341 (Core: AP and HM)

17. Zizola CF, Schwartz GJ, Vogel S. Cellular retinol-binding protein type III is a PPARgamma target gene and plays a role in lipid metabolism. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1358-68.7. PMCID: PMC2603557 (Core: AP and HM)

(Jan 2009 – Dec, 2009)

18. Blouet C, Jo YH, Li X, Schwartz GJ. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.  J Neurosci. 2009 Jul 1;29(26):8302-11. PMCID: PMC2740923  (Core: AP and MB/MG)

19. German J, Kim F, Schwartz GJ, Havel PJ, Rhodes CJ, Schwartz MW, Morton GJ.  Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.  Endocrinology. 2009 Oct;150(10):4502-11. PMID: 19574396 (Core: AP and HM)

20. Jo YH, Su Y, Gutierrez-Juarez R, Chua S Jr . Oleic acid directly regulates POMC neuron excitability in the hypothalamus.. J Neurophysiol. 2009 May;101(5):2305-16. PMCID: PMC2681442 (Core: AP and MB/MG)

21. Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.  Diabetes. 2009 Nov;58(11):2516-24. PMID: 19675136. PMCID: 2768165 (Core: AP and AT)

22. Madsen AN, Jelsing J, van de Wall EH, Vrang N, Larsen PJ, Schwartz GJ. Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents.  Neurosci Lett. 2009 Jan 2;449(1):20-3. (Core: AP and HM)

23. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ.  Autophagy regulates adipose mass and differentiation in mice.   J Clin Invest. 2009 Nov;119(11):3329-39.  PMID: 19855132 PMCID: PMC2769174 (Core: AP and AT)

24. Song CK, Schwartz GJ, Bartness TJ.  Anterograde Transneuronal Viral Tract Tracing Reveals Central Sensory Circuits From White Adipose Tissue. Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R501-11. PMID: 19109367 PMCID: PMC2665851 (Core: AP)

(Jan 2010 – May, 2010)

25. Bartness TJ, Shrestha YB, Vaughan CH, Schwartz GJ, Song CK. Sensory and sympathetic nervous system control of white adipose tissue lipolysis.  Mol Cell Endocrinol. 2010 Apr 29;318(1-2):34-43. PMID: 19747957 (Core: AP)

26. Iqbal J, Li X, Chang BH, Chan L, Schwartz GJ, Chua SC Jr, Hussain MM. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption.  J Lipid Res. 2010 Jul;51(7):1929-42. PMID: 20164094 (Core: AP and MB/MG)

27. Nagajyothi, F, Zhao, S.  Machado, F.S., Weiss L.M., Schwartz, G.J., Desruisseaux ,M.S.,   Zhao Y. Factor S.M., Huang  H., Albanese C., Mauro M., Teixeira J., Scherer , P.E., Chua Jr. S.C., Tanowitz, H.B. Trypanosoma cruzi infection in diabetic mice: role of the leptin receptor, Journal of Infections Diseases, in press. (Core: AP and MB/MG)

28. Ross, R.A., Rossetti, L., Lam, T.K.T.,  Schwartz, G.J. Differential effects of hypothalamic long chain fatty acid infusions on suppression of  hepatic glucose production, Amer. J. Physiol., in press. (Core: AP)

29. Walewski JL, Ge F, Gagner M, Inabnet WB, Pomp A, Branch AD, Berk PD. Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization .Obes Surg. 2010 Jan;20(1):93-107. (Core: AP and HM)

30. Yamada E,  Pessin, JE, Kurland, IJ,  Schwartz, GJ and  Bastie,CC, Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1,   Cell Metab. 2010 Feb 3;11(2):113-24.PMID: 20142099 (Core: AP)

Review Articles

(Jan 2006 – Dec 2006)

1.   Schwartz GJ. Integrative capacity of the caudal brainstem in the control of food intake.  Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1275-80. Review. PMCID: PMC1642699 (Core: AP)

2.   Schwartz GJ.  Dirty dealing: hepatic vagal afferents reshuffle fat distribution. Cell Metab. 2006 Aug;4(2):103-5. Review.PMID: 16890537 (Core: AP)

(Jan 2009 – Dec 2009)

3.   Schwartz GJ.  Your brain on fat: dietary-induced obesity impairs central nutrient sensing. Am J Physiol Endocrinol Metab. 2009 May; 296(5): E967-8. PMCID: PMC2681304 (Core: AP)

(Jan 2010 -  Dec 2010)

4.   Blouet C, Schwartz GJ. Hypothalamic nutrient sensing in the control of energy homeostasis.  Behav Brain Res. 2010 May 1;209(1):1-12. PMID: 20035790  (Core: AP)

5.   Schwartz GJ.  Brainstem Integrative Function in the Central Nervous System Control of Food Intake.  Forum Nutr. 2010;63:141-151.  PMID: 19955782 (Core: AP)


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