Joseph R. Vasselli, Ph.D.



EDUCATION

1962 B.A. Psychology, Columbia College, New York City
1969 M.A. Experimental Psychology, Columbia University, NYC
Thesis: Responding for food reward by mice on differential-rate-low (DRL) schedules.
Sponsor: Dr. D. Ehrlich
1975 Ph.D. Physiological Psychology, Columbia University, NY
Thesis: Conditioned effects of insulin and 2-deoxy D-glucose on the food intake of rats.
Sponsor: Dr. S.C. Woods (unpublished)

POSTDOCTORAL TRAINING

1975-76 NIMH Postdoctoral Fellowship in Neuroscience of Feeding
Brooklyn College of CUNY
Sponsor: Dr. Anthony Sclafani
1976-78 NIH Postdoctoral Fellowship in Nutrition and Endocrinology
Columbia University Institute of Human Nutrition
Sponsor: Dr. M.R.C. Greenwood

MILITARY SERVICE

PROFESSIONAL SOCIETIES

ACADEMIC APPOINTMENTS

1974-75 Instructor, Department of Psychology, Brooklyn College of the City University of New York
1975-76 Postdoctoral Fellow, Department of Psychology, Brooklyn College of the City University of New York
1976-78 Postdoctoral Fellow, Columbia University Institute of Human Nutrition, New York, NY
1978-85 Research Associate, Department of Medicine, St. Luke's-Roosevelt Hospital, New York, NY
1985-94 Principal Staff Scientist and Director, Metabolic Research Laboratory, Miles Institute for Preclinical Pharmacology, West Haven, CT
1994- Research Associate, Department of Medicine, St. Luke's-Roosevelt Hospital, New York, NY
2004- Associate Research Scientist, Columbia University Institute of Human Nutrition, NYC

HONORS

1973-75 Columbia University Faculty Fellow, Department of Psychology
1995- Fellow, North American Association for the Study of Obesity
1997-00 Treasurer, Society for the Study of Ingestive Behavior
2002-03 President, Society for the Study of Ingestive Behavior

SELECTED INVITED LECTURESHIPS / SEMINARS

The Role of Fat Cell Size and Number in the Development of Obesity.
Department of Behavioral Medicine
Southern Illinois University, Carbondale, IL, April, 1984

Peripheral Regulation of Metabolism and Energy Intake.
FASEB Summer Workshop on Energy Balance Regulation,
Saxtons River, VT, August, 1989

The Potential of a-Glucosidase Inhibition for Diabetes Treatment.
Lessons from Animal Diabetes, 3rd International Workshop,
Jerusalem, Israel, March, 1990

Pharmacology and Therapeutic Potential of a-Glucosidase Inhibitors
6th International Congress on Obesity: Pharmacological Treatment of Obesity
Yokohama, Japan, October, 1990

Regulatory Functions of Adipose Tissue: Appetite
Department of Nutrition and Food Science
University of Georgia, Athens, February 18, 1993

Leptin, a New Adipose Tissue-Derived Regulatory Hormone
John P. McGrath Public Lecture,
Long Island University, Brookville, NY, June 11, 1996
Advances in Obesity Research and Treatment
Georgia Nutrition Congress Annual Meeting
Atlanta, GA March 7, 1997

The Pathophysiology of Obesity
Rush Presbyterian-St. Luke's Medical Center
Chicago, IL October 4, 1997

Factors Regulating Food Intake in Health and Disease
Serono International Symposium: Current Developments in the Evaluation
and Treatment of Malnutrition
Huntington Beach, CA December 4, 1998

Obesity: New Concepts in Etiology and Treatment.
New York Institute of Technology, Old Westbury, NY, January 7, 2000.

Weight Regulatory Functions of the Hormone Leptin
Biological Sciences Joint Symposium
University of Florida, Gainesville, FL October 11, 2002

Leptin Resistance - Basic Mechanisms and Potential Role in Human Obesity
Obesity Drug Development Summit
Sheraton National, Arlington, VA July 21, 2005

DEPARTMENTAL AND UNIVERSITY COMMITTEES

1980-90Chair, Columbia University Seminar on Appetitive Behavior
1994 - Coordinator, Department of Medicine Endocrine-Metabolic Research Conference, St. Luke's-Roosevelt Hospital Center
2000-Member, Neurobiology Research Group, Departments of Biology and Psychology, Columbia University and Barnard College

TEACHING EXPERIENCE / RESPONSIBILITIES

A. Graduate Level

Columbia University Institute of Human Nutrition
Columbia University Teachers College, Department of Nutrition Education
Rutgers University Department of Nutritional Sciences
Thesis / Research Supervision

Mentor for Masters level thesis projects at Columbia University Institute of Human Nutrition:
1991-1992 Carolyn Munch Preventive effects of carbohydrate absorptive inhibition on streptozotocin-induced diabetes in rats.
1995-1996 Karen ChuFeeding inhibitory effects of injected leptin in genetically obese and lean rats.
2000-2001 Elizabeth GardunoStimulation of peripheral lipolysis in rats following central leptin injection determined by plasma FFA concentrations.
2002-2003Christopher XavierEffects of central leptin administration on lipolysis in peripheral adipose tissue samples.
2003-2004 Stephen TrasinoLongitudinal changes in body weight following rosiglitazone treatment in rats fed high- and low-fat diets.
2004-2005 Rozina AliEffects of an orally administered PPAR-- agonist on leptin level and action in normal rats.
B. Undergraduate Research Supervision - Independent Research, Columbia College Biology Dept.

1997-1998 Kimberly Singh Sigma Xi Student Grant-In-Aid Award, ($1000)
Effect of insulin administration on leptin release in vivo in lean and dietary obese rats.
2004-2005 Jorge Moreno Sigma Xi Student Grant-In-Aid Award, ($1,000)
Ghrelin-induced feeding stimulation and leptin resistance in dietary obese rats.

OTHER PROFESSIONAL ACTIVITIES

REVIEWER FOR THE FOLLOWING JOURNALS

PUBLICATIONS (* indicates senior authorship)

A. Original, Peer Reviewed Articles

  1. Warner, V.D., Warner, A.M., Vasselli, J.R., Decke, E., Pi-Sunyer, F.X. and Woods, S.C. Leucine and its derivatives as potential elicitors of insulin secretion in rats. J. Pharmaceut. Sci. (1973) 62 (7): 1168-1188.
  2. Lotter, E., Woods, S.C. and Vasselli, J.R. Schedule-induced polydipsia: an artifact. J. Comp. Physiol. Psychol. (1973) 83 (3): 478-484.
  3. Woods, S.C., Vasselli, J.R., Kaestner, E., Szkmary, G.A., Milburn, P. and Vitiello, M. Conditioned insulin secretion and meal feeding in rats. J. Comp. Physiol. Psychol. (1977) 91(1): 128-133.
  4. Woods, S.C., Vasselli, J.R. and Milam, K.M. Iron appetite and latent learning in rats. Physiology and Behavior (1977) 19: 623-626.
  5. Sclafani, A., Koopmans, H.S., Vasselli, J.R. and Reichman, M. Effects of intestinal bypass surgery on appetite, food intake and body weight in obese and lean rats. American J. Physiol. (1978) 234(4): E389-E398.
  6. Vasselli, J.R. and Sclafani, A. Hyperreactivity to aversive diets in rats produced by injections of insulin or tolbutamide, but not by food deprivation. Physiology and Behavior. (1979) 23: 557-567.*
  7. Vasselli, J.R., Cleary, M.P., Jen, K.C. and Greenwood, M.R.C. The development of food motivated behavior in free-feeding and food restricted Zucker fatty (fa/fa) rats. Physiology and Behavior (1980) 25(4): 565-574.*
  8. Cleary, M.P., Vasselli, J.R. and Greenwood, M.R.C. Development of obesity in the Zucker obese (fa/fa) rat in the absence of hyperphagia. American J. Physiol. (1980) 238: E284-E292.
  9. Cleary, M.P. and Vasselli, J.R. Reduced organ growth when hyperphagia is prevented in genetically obese (fa/fa) Zucker rats. Proc. Soc. Exp. Biol. Med. (1981) 167: 616-623.
  10. Vasselli, J.R., Haraczkiewicz, E. and Pi-Sunyer, F.X. Effects of acarbose (BAY G 5421) on body weight, insulin and oral glucose and sucrose tolerance in sucrose-consuming rats. Nutrition and Behavior (1982) 1(1): 21-32.*
  11. Vasselli, J.R., Haraczkiewicz, E., Maggio, C.A. and Greenwood, M.R.C. Effects of a glucosidase inhibitor (Acarbose, BAY G 5421) on the development of obesity and food motivated behavior in Zucker (fa/fa) rats. Pharmacol. Biochem. Behav. (1983) 19(1): 85-96.*
  12. Maggio, C.A., Greenwood, M.R.C. and Vasselli, J.R. The satiety effects of intragastric macronutrient infusions in fatty and lean Zucker rats. Physiology and Behavior (1983) 31(3): 367-372.
  13. Maggio, C.A., Yang, M.U. and Vasselli, J.R. Developmental aspects of macronutrient selection in genetically obese and lean rats. Nutrition and Behavior (1984) 2: 95-110.
  14. Vasselli, J.R. Carbohydrate ingestion, appetite, and obesity. Appetite (1985) 6: 53-59.*
  15. Maggio, C.A., Presta, E., Bracco, E.F., Vasselli, J.R., Kissileff, H.R., Pfohl, D.N., and Hashim, S.A. Naltrexone and human eating behavior: A dose-ranging inpatient trial in moderately obese men. Brain Research Bulletin (1985) 14(6): 657-661.
  16. Maggio, C.A., Vasselli, J.R. and Van Itallie, T.B. Changes in appetitive behavior following fasting and food restriction. Medicographia (1986) 8(2): 10-13.
  17. Maggio, C.A., DeCarr, L.B. and Vasselli, J.R. Differential effects of sugars and the alpha-glucosidase inhibitor acarbose (BAY G 5421) on satiety in the Zucker obese rat. International J. Obesity (1987) 11(S3): 53-36.
  18. Vasselli, J.R., Flory, T. and Fried, S.K. Insulin binding and glucose transport in adipocytes of acarbose-treated Zucker lean and obese rats. International J. Obesity (1987) 11(S3): 71-75.*
  19. Maggio, C.A., Haraczkiewicz, E. and Vasselli, J.R. Diet composition alters the satiety effect of cholecystokinin in lean and obese Zucker rats. Physiology and Behavior (1988) 43: 485-491.
  20. VanderWeele, D.A., Haraczkiewicz, E. and Vasselli, J.R. Tolbutamide affects food ingestion in a manner consistent with its glycemic effects in the rat. Physiology and Behavior (1988) 44: 679-683.*
  21. Maggio, C.A. and Vasselli, J.R. Satiety in the obese Zucker rat: effects of carbohydrate type and acarbose (BAY G 5421). Physiology and Behavior (1989) 46 (3): 467-470.
  22. Vasselli, J.R. a-Glucosidase inhibition with acarbose: a new therapeutic concept for diabetes. Miles Science Journal (1989) 1(1): 30-36.*
  23. Vasselli, J.R. and Maggio, C.A. Diet composition determines course of hyperphagia in developing Zucker obese rats. Physiology and Behavior (1990) 48: 805-811.*
  24. Katovich, M.J., Meldrum, M.J. and Vasselli, J.R. Beneficial effects of dietary acarbose in the diabetic rat. Metabolism (1991) 40:1275-1282
  25. Vasselli, J.R., Fiene, J.A. and Maggio, C.A. Relationship of adipocyte size to hyperphagia in the developing male Zucker obese rat. American J. Physiol. (1992) 262: R33-R38.*
  26. Cohen, M.P., Vasselli, J. R., Neuman, R. G. and Witt, J. Beneficial effects of acarbose on glycemia and microalbuminurea in streptozotocin-diabetic rats. General Pharmacology (1995) 26(6): 1355-61.
  27. Plata-Salaman, C.R., Vasselli, J.R. and Sonti, G. Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexia. Obesity Research (1997) 5: 36-42.
  28. Wright, B. E., Vasselli, J.R. and Katovich, M.J. Positive effects of acarbose in the diabetic rat are not affected by feeding schedule. Physiology and Behavior (1998) 63(5): 867-874.
  29. Heymsfield, S.B., Allison, D.B., Vasselli, J.R., Pietrobello, A., Greenfield, D. and Nunez, C. Garcinia Cambogia: A randomized double-blind controlled study of a potential anti-obesity agent. JAMA (1998) 280(18): 1596-1600.
  30. Tang H, Vasselli J, Wu EX, Gallagher D. In-vivo determination of body composition in rats using high resolution magnetic resonance imaging. Ann NY Acad Sci (2000) 904: 32-41.
  31. Rosenbaum, M., Pietrobelli, A., Vasselli, J.R., Heymsfield, S.B. and Leibel, R.L. Sexual dimorphism in circulating leptin concentrations is not accounted for by differences in adipose tissue distribution. International Journal of Obesity (2001) 25: 1365-1371.
  32. Vasselli, J.R. Behavioral and biological determinants of leptin resistance. Appetite (2001) 37(2): 115-117.*
  33. Tang, H., Vasselli, J.R., Wu, E.X., Boozer, C. and Gallagher, D. High resolution magnetic resonance imaging tracks changes in organ and tissue mass in rats. American J. Physiol. (2002) 282: R890-R899.
  34. Currie, P.J., Mirza, A., Fuld, R., Park, D. and Vasselli, J.R. Ghrelin is an orexigenic and metabolic signaling peptide acting within the arcuate and paraventricular nucleus. American J. Physiol. (2005) 289: R353-R358.
  35. Singh, K.A., Boozer, C.N. and Vasselli, J.R. Acute insulin-induced elevations of circulating leptin and feeding inhibition in lean and obese rats. American J. Physiol (2005) 289: R373-R379.*
  36. Vasselli, J.R., Weindruch, R., Heymsfield, S.B., Pi-Sunyer, F.X., Boozer, C.N., Yi, N., Wang, C., Pietrobelli, A. and Allison, D.B. Intentional weight loss reduces mortality rate in a rodent model of dietary obesity. Obesity Research (2005) 13:693-702.*
  37. Garduno, E.R., Currie, P.J., Chen, K., Johnson, J.A. and Vasselli, J.R. Intracerebroventricular (ICV) leptin stimulates peripheral lipolysis in rats at a feeding-inhibitory dose. Brain Research, (2005), Submitted. *
B. Books

  1. Drugs In Development, Vol. 1. a-Glucosidase Inhibition: Potential Use in Diabetes. J.R. Vasselli, C.A. Maggio and A. Scriabine Eds. (1993) Neva Press, Branford, CT.
C. Reviews, Chapters and Editorials

  1. Woods, S.C., Decke, E. and Vasselli, J.R. Metabolic hormones and regulation of body weight. Psychological Reviews. (1974) 81 (1): 26-43
  2. Woods, S.C., Kaestner, E. and Vasselli, J.R. Insulin, growth hormone, body weight and feeding: a reply to Panksepp. Psychological Reviews (1975) 82 (2): 165-168.
  3. Greenwood, M.R.C. and Vasselli, J.R. The effects of nitrogen and caloric restriction on adipose tissue, lean body mass, and food intake in genetically obese rats: The LPL hypothesis. R.F. Beers, Jr. and E.G. Bassett, Eds. Nutritional Factors: Modulating Effects on Metabolic Processes Raven Press, New York, NY (1981) 323-335.
  4. Vasselli, J.R. and Haraczkiewicz, E. Intestinal glucosidase inhibition: effects upon food intake and the development of obesity in 2 rat models. W. Creutzfeldt, Ed. Proceedings, First International Symposium on Acarbose, Excerpta Medica, Amsterdam (1982) 161-166. *
  5. Greenwood, M.R.C., Cleary, M.P., Steingrimsdottir, L. and Vasselli, J.R. Adipose tissue metabolism and genetic obesity: The LPL hypothesis. P. Bjorntorp, M. Cairella and A.N. Howard, Eds. Recent Advances in Obesity Research: III. John Libbey, London. (1981) 75-79.
  6. Vasselli, J.R., Cleary, M.P. and Van Itallie, T.B. Modern concepts of obesity. Nutrition Reviews (1983) 41 (12): 361-373. *
  7. Vasselli, J.R., Cleary, M.P. and Van Itallie, T.B. Obesity. Present Knowledge in Nutrition, 5th edition, The Nutrition Foundation, Washington, DC (1984) 35-56. *
  8. Vasselli, J.R. Patterns of hyperphagia in the Zucker obese rat: a role for fat cell size and number- Brain Research Bull. (1985) 14(6): 633-641. *
  9. Vasselli, J.R. and Maggio, C.A. Mechanisms of appetite and body weight regulation. R.T. Frankle and M.U. Yang, Eds. Obesity and Weight Control: The Health Professional's Guide to Understanding and Treatment, Aspen Publishers, Inc., Rockville, MD (1987) 17-34. *
  10. Fried, S.K., Maggio, C.A. and Vasselli, J.R. Effects of acarbose on insulin sensitivity in adipocytes of lean and obese Zucker and Zucker diabetic-fatty rats. J.R. Vasselli, C.A. Maggio and A. Scriabine, Eds. a-Glucosidase Inhibition: Potential Use in Diabetes. Neva Press, Branford, CT. (1993) 85-93.
  11. Vasselli, J.R., DeCarr, L.B. and Velazquez, N. Effects of acarbose on lipid and lipoprotein metabolism in normal and insulin-deficient diabetic rats. J.R. Vasselli, C.A. Maggio and A. Scriabine, Eds. a-Glucosidase Inhibition: Potential Use in Diabetes, Neva Press, Branford, CT. (1993) 125-132. *
  12. Maggio, C.A., Vasselli, J.R. and Pi-Sunyer, F. X. Acarbose attenuates development of streptozotocin (STZ)-induced diabetes in sucrose-consuming rats. J.R. Vasselli, C.A. Maggio and A. Scriabine Eds. In a-Glucosidase Inhibition: Potential Use in Diabetes, Neva Press, Branford, CT (1993) 181-188.
  13. Vasselli, J.R. and Maggio, C.A. Mechanisms of appetite and body weight regulation. S. Dalton, Ed. Overweight and Weight Management, Aspen Publishers, Gaithersburg, MD (1997) 187-201. *
D. Selected Abstracts

  1. Boozer, C.N., Zekser, D. and Vasselli, J.R. Isocaloric feeding of high fat versus low fat diet produces increased hunger in rats. (1996) FASEB J. 10(3): A561.
  2. Heymsfield, S.B., Pietrobelli, A., Vasselli, J.R., Grammes, J. and Allison, D.B. Serum leptin levels: development and cross-validation of prediction models for estimating total body fat. (1996) Obesity Research 4(1): 43S.
  3. Ishikawa, M., Flynn, M.C., Blackburn, G.L., Harrington, M., Heymsfield, S.B., Pietrobello, A., Vasselli, J.R., Grammes, J., Hackett, C., Manyak, C. and Staten, M. Can serum leptin concentrations serve as a biomarker of high risk obesity- (1996) Obesity Research 4(1): 35S.
  4. Sonti, G., Vasselli, J.R. and Plata-Salaman, C.D. Cytokine-induced anorexia in obese (fa/fa) and lean (Fa/Fa) Zucker rats: differential sensitivity to the ICV administration of cytokines. (1996) Appetite 27(3): 307.
  5. Vasselli, J.R. and Casey, D. Increased responsiveness of Zucker obese rats to the feeding- inhibitory effects of systemically injected TNF-a. (1996) FASEB J. 10(3): A823.
  6. Vasselli, J.R., Plata-Salaman, C.R., Kissileff, H.R., Casey, D. And Sonti, G. Differential feeding- inhibitory effects of peripheral and central cytokine administration in Zucker obese (fa/fa) and lean (Fa/Fa) rats. (1996) Society for Neuroscience Abstracts 22(1): 460.
  7. Vasselli, J.R. and Casey, D. Enhanced responsiveness of Zucker fa/fa rats to the feeding-inhibitory effect of systemic TNF-a. (1996) Appetite, 27(3): 311-312.
  8. Pietrobelli, A., Vasselli, J.R., Heymsfield, S.B., Blackburn, G.L., Ishikawa, M. and Miller, D.L. Hyperinsulinemia is not a necessary condition for elevated leptin in obese human females. (1997) FASEB J., 11(3): A171.
  9. Vasselli, J.R., Chu, K. and Maggio, C.A. Differential responsiveness of Zucker obese (fa/fa), lean (Fa/Fa) and Sprague-Dawley (S-D) rats to subcutaneous injections of murine leptin (rMuLep). (1997) FASEB J., 11(3): A357.
  10. Pietrobelli, A., Vasselli, J.R., Faith, M.S., Allison, D.B., Heymsfield, S.B., Beccaria, L., Chiumello, G. and Campfield, L.A. Is the relationship between leptin and insulin levels the same for individuals with and without Prader-Willi syndrome- (1997) Horm Res 48 (S2): 182.
  11. Vasselli, J.R., Chu, K. and Maggio, C.A. Differential effects of subcutaneous injections of rMuLeptin on feeding and body weight in genetically obese, lean and Sprague-Dawley rats. (1997) Appetite 29 (3): 418.
  12. Vasselli, J.R., Shane, E., Boozer, C.N., and Heymsfield, S.B. Garcinia Cambogia extract inhibits body weight gain via increased energy expenditure (EE) in rats. (1998) FASEB J. 12(4) Part I: A505.
  13. Heymsfield, S.B., Allison, D.B., Nunez, C., Greenfield, D., Wolper, C., Pietrobelli, A. and Vasselli, J.R. A randomized clinical trial of the efficacy of Garcinia Cambogia for weight and fat loss in association with a low calorie diet. (1998) Int. J. Obesity 22 (S3): 118.
  14. Vasselli, J.R., Rosenbaum, M., Pietrobelli, A., Leibel, R.L., Nicolson, M., and Heymsfield, S.B. Sexual dimorphism in circulating leptin concentrations is not accounted for by dimorphism in adipose tissue distribution. (1998) Int. J. Obesity 22 (S3): 268.
  15. Vasselli, J.R., Chu. K, Kissileff, H.R., and Maggio, C.A. Resistance to the feeding and body weight-inhibitory effects of peripherally-injected leptin (rMuLep) in Zucker obese and lean rats. (1998) Society for Neuroscience Abstracts, 24(Part 1): 449.
  16. Chou, C.J., Vasselli, J.R., Boozer, C.N. and Pi-Sunyer, F.X. Use of a mitochondrial swelling technique to measure total uncoupling activity in various tissues. (1999) FASEB J. 13(5): Part II: A926.
  17. Singh, K., Boozer, C.N., Saland, S. and Vasselli, J.R. Relationship between insulin-induced increases of circulating leptin and feeding inhibition in lean and obese rat strains. (1999) FASEB J. 13(5): Part I: A559.
  18. Vasselli, J.R., Singh, K., Boozer, C.N. and Saland, S. Insulin-induced elevations of circulating leptin and feeding inhibition in lean and dietary obese rats. (1999) Appetite 33(2): 225.
  19. Vasselli, J.R., Greenfield, D., Schwartz, L. and Heymsfield, S.B. Consumption of a pre-meal drink containing protease inhibitor from potatoes decreases hunger and increases fullness in overweight subjects following a meal. (1999) Obesity Research 7(S1): 18S.
  20. Testolin, C., Vasselli, J.R., Heshka, S., Lee, R., Phillips, S.B. and Heymsfield, S.B. Leptin: independent influence of skeletal muscle mass on serum levels. (1999) Obesity Research 7(S1): 46S.
  21. Tang, H., Vasselli, J.R., Wu, E., Choi, A. and Gallagher, D. In vivo study of body composition in rats using high resolution magnetic resonance imaging. (1999) Obesity Research 7(S1): 129S.
  22. Vasselli, J.R., Singh, K.A., Boozer, C.N. and Saland, S. Feeding-inhibitory responses of lean and obese Sprague-Dawley rat sub-strains to insulin-induced elevations of endogenous leptin. (1999) Obesity Research 7(S1): 34S.
  23. Johnson, J.A., Ng, K.W., Albu, J.A. and Vasselli, J.R. High fat fed rats resistant to the feeding-inhibitory effects of leptin are responsive to its lipolytic effect in adipose tissue. (2000) Obesity Research 8(S1): 22S.
  24. Vasselli, J.R., Koczka, C.P., Singh, K.A., Boozer, C.N., and Maggio, C.A. Expression of leptin resistance: role of diet vs. increased adiposity. (2000) Obesity Research 8(S1): 14S.
  25. Hoffman, D.J., Vasselli, J.R., Pugh, T., Weindruch, R. and Allison, D. Oxidative damage in the nuclei. of islet cells and obesity. Obesity Research 8(S1): 116S, 2000.
  26. Tang, H., Vasselli, J.R., Wu, E., Boozer, C.N., Reda, T. and Gallagher, D. High resolution magnetic resonance imaging (MRI): an in vivo validation study of body composition in rats. (2000) Obesity Research 8(S1): 17S.
  27. Vasselli, J.R. Role of diet, leptin level, and obesity in the expression of leptin resistance. (2000) Appetite 35(3): 3.
  28. Vasselli, J.R., Koczka, C.P., Singh, K.A., Boozer, C.N., and Maggio, C.A. Expression of leptin resistance: role of diet vs. increased adiposity. (2000) Obesity Research 8(S1): 14S.
  29. Johnson, J.A., Ng, K.W., Albu, J.A. and Vasselli, J.R. High fat fed rats resistant to the feeding-inhibitory effects of leptin are responsive to its lipolytic effect in adipose tissue. (2000) Obesity Research 8(S1): 22S.
  30. Johnson, J.A., Ng, K.W., Albu, J.B. and Vasselli, J.R. Leptin dose-dependently decreases the nonesterified fatty acid/glycerol ratio in adipocytes from rats fed high- and low-fat diets. (2001) Obesity Research 9 (S3) 64S.
  31. Vasselli, J.R., Johnson, J.A., Burguera, B, Zang, Y. and Scarpace, P. Altered STAT-3 phosphorylation in high-fat fed, leptin resistant, rats. (2002) Obesity Research 10(1): 67.
  32. Vasselli, J.R., Koczka, C.P., Lee, I., Sabo, A., Casey, D.E. and Allison, D.B. Development of a rodent model of antipsychotic drug-induced obesity. (2002) American J Clin. Nutrition. 75(2S) 412S-413S.
  33. Vasselli, J.R., Johnson, J., Burguera, B., Zang, Y. and Scarpace, P. Altered STAT-3 phosphorylation in high fat-fed, leptin resistant rats. (2002) American J Clin Nutrition 75(2S): 353S.
  34. Garduno, E.R., Currie, P.J., Chen, K., Johnson, J.A. and Vasselli, J.R. Intracerebroventricular (ICV) leptin administration stimulates peripheral lipolysis in rats at a feeding-inhibitory dose. (2003) Appetite 40(3): 332.
  35. Vasselli, J.R., Lee, I. and Allison, D.B. A rat model of antipsychotic drug-induced weight gain. (2003) Appetite 40(3): 365.
  36. Currie, P.J., Mirza, R, Fuld, R. and Vasselli, J.R. Metabolic and orexigenic action of ghrelin following microinjection into the arcuate and paraventricular nuclei of the hypothalamus. (2003) Society for Neuroscience 33rd Annual Meeting.
  37. Vasselli, J.R., Coiro, C.D., and Currie, P.J. Alterations in responsivity to sweet solutions in dietary obese Sprague-Dawley rats. (2003) Obesity Research 11(S): A115.
  38. Vasselli, J.R., Yi, N., Boozer, C.N., Heymsfield, S.B., Pi-Sunyer, F.X., Pietrobelli, A., Weindruch, R. and Allison, D.B. Caloric restriction-induced weight loss decreases mortality in dietary obese Sprague-Dawley rats. (2003) Obesity Research 11(S): A69.
  39. Wu, E.W., Tang, H. and Vasselli, J.R. MRI assessment of the growth effects of anabolic steroids in a guinea pig model. (2004) Proceedings International Society of Magnetic Resonance in Medicine 11: 43.
  40. Vasselli, J.R., Coiro, C.D., and Currie, P.J. Decreased sweet solution preference in dietary obese Sprague-Dawley rats. (2004) Appetite 43(3): 406.
  41. Vasselli, J.R., Moreno, J., Johnson, J.A., Garel, V. and Currie, P. Effects of central and peripheral ghrelin on feeding in dietary obese leptin-resistant rats. Submitted to SSIB Annual Meeting, July, 2005
  42. Johnson, J.A., Trasino, S.E. and Vasselli, J.R. Persistence of decreased adipocyte size after rosiglitazone treatment in rats fed high- and low-fat diets. Submitted to NAASO Annual Meeting, October, 2005
  43. Vasselli, J.R. Moreno, J.O., Johnson, J.A., Garel, V. and Currie, P. Degree of leptin resistance in rats maintained on a high-fat diet is a function of body weight. Submitted to NAASO Annual Meeting, October, 2005
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