The New York Obesity Nutrition Research Center
The Irving Institute for Clinical and Translational Research (Columbia CTSA) http://irvinginstitute.columbia.edu/index.html

Columbia University (CU) has a Clinical and Translational Science Award (CTSA) from the National Institutes of Health, National Center for Research Resources. Henry N. Ginsberg, MD, Associate Dean for Clinical and Translational Research, and Herbert and Florence Irving Professor of Medicine, is principal investigator. This award, together with increased support from the Herbert Irving Foundation, has allowed Columbia to create the Irving Institute for Clinical and Translational Research (IICTR). Building upon Columbia’s general clinical research center (the former Irving Center for Clinical Research), the IICTR serves as the academic and intellectual home for the next generation of investigators at CU. Continuing the tradition of outstanding clinical research first started at CU in 1928, the focus of the IICTR is to transform the way clinical and translational research is conducted, enabling medical investigators to develop new treatments faster, and to deliver those treatments to patients more efficiently and effectively.
 
Senior faculty who are funded by the CTSA provide outstanding support and resources to IICTR users including research in a) biomedical informatics, b) biostatistical and clinical trial design, c) bioethics, d) regulatory issues, e) patient-oriented research, and d) core laboratory resources, among others. As part of the CTSA program, the Irving Institute houses an integrated educational program that includes a patient-oriented master’s degree, a novel K12 mentored research program in multi- and inter-disciplinary research and a pre-doctoral clinical and translational certificate. The chief goal of the IICTR and CTSA is to more directly utilize medical research advances to benefit patients and the community, converting knowledge into practice.

SLRHC CRR (part of Columbia CTSA)
The inpatient scatter beds and outpatient facilities at the SLRHC, a satellite of the CRC at the CU Irving Center CTSA, provide infrastructure for clinical research activities with a focus on studies of Nutrition and Metabolism. Unique amenities, including a Human Room Calorimeter, allow sensitive and specific measurements of Body Composition and Energy Metabolism. These facilities and services make the SLRHC satellite a national resource in this area of research.

The Inpatient Scatter Bed Clinical Research activities occur in specifically designated research patients’ rooms on a general medicine ward, in close proximity to the Clinical Research Office of the CRC personnel, the CRC Physiology Room and the Metabolic Pantry (used for food packaging and serving). Nearby are 3 rooms for Human Ingestive Studies, and the Two-Chamber Human Room Calorimeter: NYONRC facilities also used for CRC protocols.

The Outpatient Clinical Research activities are carried out on the CRC ambulatory care facility (Outpatient Research). This 1,769 square foot space contains 4 examining rooms, 2 of which contain hospital beds for prolonged outpatient procedures. The facility is close to NYONRC laboratories and the postdoctoral fellows’ offices. Scheduling is done electronically through the SLRHC Intranet, and medical coverage for emergencies and emergency procedures is in place. The Unit is regularly inspected by the Quality Control team of the Hospital Center with regard to JACHO compliance. Pediatric outpatient clinical research studies are supported by CRC personnel in the Pediatric Body Composition Clinical Research area.

The CRC personnel provide routine research services (iv insertions, frequent blood draws, phlebotomy, supervised meal tests, frequent vital signs monitoring, etc.), but are also fully trained in specialized research protocols (meal tests, oral and intravenous glucose tolerance tests, various euglycemic clamps protocols, indirect calorimetry by cart and chamber, supervised exercise testing, etc). Services are provided by the CRC personnel on the inpatient and outpatient units from 7AM till 4PM daily. General nursing services are provided by nurses on the in-patient medical floor for the patients on the scatter beds 24 hours a day. Overnight research personnel could be provided through special arrangement. The GCRC is equipped with 6 Gemini PC-1® Single-Channel Infusion Systems (Alaris Medical Systems), one automatic blood pressure machines GE Medical Systems DINAMAP PRO 100 V2 Monitor, two EKG machine, caliper and tape measures, precision scales and stadiometers for anthropometric measurements.


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