Blandine Laferrère, M.D.



Academic Training

Traineeship

Research, Academic Appointments and Hospital Appointments

1989-1991 Chief of Clinic and Teaching Assistant, Department of Medicine, Division of Nutrition and Metabolism, Hospital Hotel-Dieu, Paris, France
1998-present Research Associate, Obesity Research Center, NY
1996-present Attending, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, St.Luke's-Roosevelt Hospital Center
1996-present Assistant Professor in Clinical Medicine, Columbia University, College of Physician & Surgeons, New York, NY

Board Membership

Teaching Experience and Responsibilities

Professional Organizations

Awards and Honors

1987Gold Medal of Hospices Civils of Lyon
1987Grant from Jean Walter Zelidja Foundation
1988Grant from French Foundation for Nutrition
1998Career Award from American Diabetic Association
1998Grant from NIH K08 DK 02 572-01
2002Grant from NIH -Irving Center for Clinical Research Pilot Award
2003Grant from NIH R03 DK 062939-01
2003Grant from NIH Pilot and Feasibility
2005NIH NIDDK R01 DK-067561-01
2005American Diabetes Association Clinical Research Award 7-05-CR-18
2005Irving Center for Clinical Research Award
2005NIH NIDDK R01 DK-067561-01
2006DERC Pilot and Feasibility

Publications

  1. Sassolas G, H.Rousset, R.Cohen, P.Chatelain, B.Claustrat, S.Laporte, B.Laferrèe, A El Charfi, S.Ferry. Gonadotropin Releasing Hormone releases Growth Hormone in a child with Growth Hormone deficiency of hypothalamic origin, C.R. Acad. Sc. Paris 1983,296,527-530.
  2. Bernier M, B.Laferrèe, C.Jaillard, M.Clerget, J.M.Saez. Regulation of gonadotropin receptors on cultured porcine Leydig and Sertoli cells: effects of potassium depletion, Endocrinology, 1986,118 (6),2254-61
  3. Laferrère B, A.M.Madek, J.Orgiazzi, R.Mornex. Study of biological markers of Grave's ophthalmopathy without thyrotoxicosis in 29 cases, Presse Médicale,1987,16 (15),711-14
  4. Laferrère B, Wurtman RJ, Effect of D-fenfluramine on serotonin release in brains of anesthetized rats. Brain Res. 1989,504:258-63
  5. Wurtman JJ, Brzezinski A, Wurtman RJ, Laferrèe, B. Effect of nutrient intake on premenstrual depression, Am. J. Obstet. Gynecol.,1989,161,1228-1234.
  6. Bret M, Broussole C, Laferrère B, Souquet JC, Orgiazzi, J. Study of efficacy and tolerance of an intragastric balloon in the treatment of morbid obesity, La Presse Médicale,1990,19(24),1153
  7. Laferrère B, Nguyen, M, Bonhomme, G, Le Gall A, Basdevant A, Guy-Grand B. Effect of BIM18216, a novel cholecystokinin receptor antagonist, on the reduction of food intake induced by cholecystokinin, Behavioral Neuroscience,1991,105 (5), 705-709
  8. Laferrère B. Cholecystokinin and food intake: a review, Cahiers de Nutrition, 1991, 26 (5), 317-323
  9. Laferrère B, Leroy, F, Bonhomme G, Le Gall A, Basdevant A, Guy-Grand B. Effect of bombesin, a new bombesin agonist (BMI187) and antagonist (BMI189) on food intake in rats, in relation to cholecystokinin, European Journal of Pharmacology, 1992,215 (1),23-28
  10. Laferrère B, Lahlou N, Saltiel H, Roger M. Basdevant A, Guy-Grand B. Hypersensitivity of the corticotropic axis to the serotoninergic agent clomipramine in obese women, Obesity Research, 1994, 2 (4), 328-336
  11. Oppert JJM, Lahlou N, Laferrère B, Roger M. Basdevant A, Guy-Grand B. Plasma leptin and acute serotoninergic stimulation of the corticotropic axis in obese women, Obesity Research, 1997, 5(5) 410-416.
  12. Laferrère B, S. Fried, K. Hough, S. Campbell, J.Thornton and FX. Pi-Sunyer , Synergistic effect of feeding and dexamethasone on leptin serum levels in humans. J Clin Endocrinol Metab, 83 (10) 3742-3745,1998.
  13. Pi-Sunyer FX, Laferrère B, Metabolic abnormalities and the role of leptin in obesity, a review. J Clin Endocrinol Metab 84(1)3-12,1999.
  14. Laferrère B, Funkhouser ABS, Thornton JC, Pi-Sunyer FX, Total body calcium (TBCa) in obese women: validation of dual-energy x-ray absorptiometry (DXA) against in vivo neutron activation analysis (IVNA). Annals of New York Academy of Sciences, 904:507-513, 2000
  15. Funkhouser AB, Laferrère B, Wang J, Thornton JC, PiSunyer FX. Measurement of body fat percent during weight loss in obese women: comparison of four methods. Ann. NY Acad. of Sci., Vol 904, p539-541,2000.
  16. Fried SK, M.R Ricci, C.D.Russel, B.Laferrèe.Regulation of leptin production in humans. J Nutr 130:3127S-3131S, 2000
  17. Laferrère B, S.K. Fried, T. Osborne and FX. Pi-Sunyer, Effect of one morning meal and a bolus of dexamethasone on 24-hour variation of serum leptin in humans, Obesity Research, 8(7)481-486, 2000
  18. Laferrère B, A. Caixas, S.K. Fried, C. Bashore, J. Kim, FX. Pi-Sunyer. A pulse of insulin and dexamethasone stimulates serum leptin in fasting human subjects. Eur J Endocrinol. 2002 Jun;146(6):839-45.
  19. Caixas A, Bashore C, Nash W., Pi-Sunyer FX, Laferrère B.. Insulin, unlike food intake, does not suppress ghrelin in human subjects. J Clin Endocrinol Metab 87(4):1902-1906, 2002
  20. Pietrobelli A, Allison DB, Heshka S, Heo M, Wang ZM, Bertkau A, Laferrère B, Rosenbaum M, Aloia JF, Pi-Sunyer FX, Heymsfield SB. Sexual dimorphism in the energy content of weight change. Int J Obes Relat Metab Disord. 2002 Oct;26(10):1339-48.
  21. Wang J, Laferrèe, B, Thornton, JC, Pierson RN, Pi-Sunyer FX. Regional subcutaneous-fat loss induced by caloric restriction in obese women. Obesity Research 10(9) 885-890, 2002
  22. Laferrère B, Zhu SK, Clarkson JR, Yoshioka MRM, Krauskopf K, Thornton JC, Pi-Sunyer FX. Race, menopause, health-related quality of life, and psychological well being in obese women. Obesity Research. 2002, 10(12) 1270-1275
  23. Wang J, Thornton JC, Bari S, Williamson B, Gallagher D, Heymsfield SB, Horlick M, Kotler D, Laferrère B, Mayer L, Pi-Sunyer FX, Pierson RN Jr. Comparisons of waist circumferences measured at 4 sites. Am J Clin Nutr 2003 Feb;77(2):379-84.
  24. Residori L, Flancbaum L, Garcia-Lorda P, Pi-Sunyer FX, Laferrère B. Prevalence of comorbidities in obese patients prior to bariatric surgery. Effect of race. Obes Surg. 2003 Jun;13(3):333-40.
  25. Garcia-Lorda P, Nash W, Roche A, Pi-Sunyer FX, Laferrère B. Intralipid/heparin infusion suppresses serum leptin in humans. European Journal of Endocrinology, 2003, 148:669-676.
  26. Averbukh Y, Heshka S, El-Shoreya H, Flancbaum L, Geliebter A, Kamel S, Pi-Sunyer FX , Laferrère B. Depression Score Predicts Weight Loss following Roux-en-Y Gastric Bypass. Obesity Surgery Dec 2003(6) 833-6.
  27. Laferrère B., Garcia-Lorda P, Russel CD, Pi-Sunyer FX. Effect of Oral Glucosamine Sulfate on Serum Leptin Levels in Human Subjects. Nutrition, 20:321-322,2004.
  28. Ward?Kamar J M. Rogers, L. Flancbaum, B. Laferrèe. Calorie intake and meal patterns up to 4 years after Roux-en-Y gastric bypass surgery. J. Obesity Surgery 14(8): 1070-9,2004.
  29. Laferrère B., Russell CD, Abraham C, Bowers CY. GHRP-2, like ghrelin, increases food intake in healthy men. J Clin Endo Metab 90(2):611-614,2005.
  30. Chung S, Song MY, Shin HD, Kim DY, He Q, Heshka S, Wang J, Thornton J, Laferrère B, Pi-Sunyer FX, Gallagher D. Korean and Caucasian Overweight Premenopausal Women Have Different Relationship of Body Mass Index to Percent Body Fat with Age. J Appl Physiol. 2005 Jul;99(1):103-7.
  31. Liou TH, Pi-Sunyer, FX, Laferrère B Physical Disability and Obesity: Nutr Rev. 2005 Oct;63(10):321-31.
  32. Fetner R, McGinty J, Russell CD, Pi-Sunyer FX, Laferrère B. Incretins, diabetes and bariatric surgery: A review Surgery for Obesity and Related Diseases, 1(6), 2005, Pages 589-597
  33. Caixas A, Gimenez-Palop O, Giminez-Perez G, Potau N, Berlanga E, Gonzalez-Glemente JM , Arroyo J, Laferrère B, Mauricio D. Postprandial adiponectin levels are unlikely to contribute to the pathogenesis of obesity in Prader-Willi syndrome. Horm Res 2005 65(1):39-45.
  34. Fetner R, McGinty J, Russell CD, Pi-Sunyer FX, Laferrère B. Incretins, diabetes and bariatric surgery: A review. Surg Obes Relat Dis 1(6) :589-597, 2005.
  35. Tounian A, Laferrère B, Guy-Grand B. Ghrelin : a review (In French) Cahiers de nutrition et de di¨¦t¨¦tique 40 (5) 270-280, 2005.
  36. Laferrère B, Abraham C, Awad M, Jean-Baptiste S, Hart A.B, Garcia-Lorda P, Kokkoris P, Russell DC. Inhibiting Endogenous Cortisol Blunts the Meal-Entrained Rise in Serum Leptin. J Clin Endo, Metab 91(6):2232-8, 2006.
  37. Laferrère B, Hart AB, Bowers C.Y. Obese subjects respond to the stimulatory effect of the ghrelin agonist Growth Hormone Releasing Peptide -2 (GHRP-2) on food intake. Obesity 14(6):1056-1063, 2006
  38. Lee H, Te C, Koshy S, Teixeira J, Pi-Sunyer FX, Laferrère B. Does ghrelin really matter after bariatric surgery? Surg Obes Relat Dis. 2: 538-548, 2006.
  39. Gim¨¦nez-Palop O, Gim¨¦ne-P¨¦rez G, Mauricio D, González-Clemente JM, Potau N, Berlanga E, Trallero R, Laferrère B, Caix¨¤s A. A lesser postprandial suppression of plasma ghrelin in Prader-Willi syndrome is associated with low fasting and a blunted postprandial PYY response. Clin Endocrinol 66:198-204, 2007.
  40. Laferrère B, Wang K, Khan Y, McGinty J, Teixeira J, Hart AB, Heshka S, Olivan B, Incretin levels and effect are markedly enhanced one month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care 30:1709-1716, 2007.
  41. Bowers C.Y., Hurley D.L., Laferrère B and Veldhuis J.D. The Role of GHSs/Ghrelin in Feeding and Body Composition, in Obesity and Energy Metabolism: Research and Clinical Applications. Ed: Patricia A. Donohue.
  42. Wu C-H, Heshka S, Wang J, Pierson, RNJr, Heymsfield SB, Laferrère B, Wang Z, Albu JB, Pi-Sunyer FX, Gallagher D. Truncal Fat in Relation to Total Body Fat: Influences of Age, Sex, Ethnicity and Fatness. Int J Obes (Lond). 2007;31(9):1384-91.
  43. Laferrère B Does surgically induced weight loss decrease mortality? Nat Clin Pract Endocrinol Metab. 2007 March 4(3) 136-137
  44. Laferrère B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A, Kovack B, Bawa B, Koshy N, Lee H, Yapp K, Olivan B. Gastric bypass surgery versus low calorie diet: Effect of weight loss on glucose and incretin levels in patients with type 2 diabetes. J Clin Endo Metab 2008 Jul;93(7):2479-85.

Abstracts (International Conferences, Last year)

  1. Laferrère B, Wang KG, Khan Y, McGinty JJ, Teixeira J, Heshka S. Impaired GLP-1 release and incretin effect are partially reversed 3to 5 weeks after gastric bypass surgery in patients with type 2 diabetes-OR54-3 Endo2006
  2. Gimenez-Palop O, Caixas A, Mauricio D, Potau N, Berlanga E, Gonzalez-Clemente J-M, Laferrère B, Gimenez-Perez G. Low fasting and post-prandial PYY levels contribute to the hyperghrelinemia in adults with Prader-Willi Syndrome. P1-653, Endo 2006.
  3. Laferrère B, Khan Y, Wang K, Yu W, Pi-Sunyer FX, Wang J. Total and Regional Body Volumes and Dimensions, %Body Fat By 3-D Photonic Image Scanner Before and 3 Months After Gastric Bypass Surgery in a Woman with Diabetes Obesity 14:A163,520-P,2006
  4. Olivan B, Wang K, Khan Y, Laferrère B. Early effect of gastric bypass surgery on insulin sensitivity and secretion in morbidly obese subjects with type 2 diabetes mellitus. Obesity 14:A164,521-P, 2006
  5. Laferrère B,, Tran HC, Egger J, Yap KP, Teixeira J, McGinty J, Olivan B. Amylin Levels Decrease 1 Month After Roux-en-Y Gastric Bypass Surgery in Patients with Type 2 Diabetes ADA 2007
  6. Laferrère B,, Tran HC, Egger J, Yap KP, Heshka S, Teixeira J, McGinty J, Olivan B. GLP-1 and GIP Levels and Effect are Markedly Enhanced One Month After Roux-en-Y Gastric Bypass Surgery in Obese Patients with Type 2 Diabetes. ADA 2007.
  7. Laferrère B, Tran H, Egger JR, Yap K, Bawa B, Teixeira J, McGinty J, Koshy N, Lee H, Olivan B. The increase in GLP-1 levels and incretin effect after Roux-en-Y Gastric bypass surgery (RYGBP) persists up to 1 year in patients with type 2 diabetes mellitus (T2DM) Obesity OR21, 2007.
  8. Laferrère B, Egger JR, Tran H, Kovack B, Colarusso A, Yap K, Bawa B, Teixeira J, McGinty J, Koshy N, Lee H, Olivan B. The changes in incretin levels and effect observed after Roux-en-Y gastric bypass surgery are a direct result of the surgery, independently of weight-loss. Obesity OR51, 2007
  9. Olivan B, Tran H, Egger J, Colarusso T Kovacs B, Yap K, Bawa B, Teixeira J, McGinty J, Lee H, Koshy N, Laferrère B. The increase in PYY 3-36 levels after Roux-en-Y gastric bypass (RYGBP) is not weight-loss dependent. Obesity, P-181,2007.
  10. Bose M, Olivan B, Teixeira JA, McGinty JJ, Colarusso A, Kovacs BL, Bawa B, Summe H, Chang T, Laferrère B Gastric Bypass Surgery Improves Post-prandial Glucose and Increases Incretin Levels More Than Diet-induced Weight Loss in Patients with Type 2 Diabetes. American Diabetes Association P1440, San Francisco, June 2008.
  11. Laferrère B,, J Wang, H Summe, R Weil, W Yu, B Kovacs, B Olivan, T Chang, B Bawa, F X Pi-Sunyer. Distribution of weight loss after bariatric surgery or a low calorie diet: Results from 3-D photonic scanner (3-DPS). International Body Composition Conference, New York July 2008
  12. Oliván B, Bose M, Teixeira JA, McGinty JJ, Colarusso A, Kovacs BL, Bawa B, Chang T, Summe H, Koshy N, Laferrère B. PYY3-36 and GLP-1 levels increase after gastric bypass but not after equivalent weight loss by diet or gastric banding. Submitted Obesity Society Meeting October 2008
  13. Bose M, Oliván B, Teixeira JA, McGinty JJ, Colarusso A, Kovacs BL, Bawa B, Chang T, Summe H, Koshy N, Laferrère B. Changes of ghrelin levels after weight loss: is bariatric surgery different than diet? Submitted Obesity Society Meeting October 2008


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