The New York Obesity Nutrition Research Center

Adipose Tissue Core Laboratory Publications

Peer Reviewed

(Jan 2006 – Dec 2006)

1.   Buteau J, Spatz ML, Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes. 2006;55(5):1190-6. (Core: AT and MGMB)

2.   Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Jr., Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49(2):191-203. (Core: AT, MGMB)

3.   Han S, Liang CP, DeVries-Seimon T, Ranalletta M, Welch CL, Collins-Fletcher K, Accili D, Tabas I, Tall AR. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab. 2006;3(4):257-66. (Core: AT, MGMB)

4.   Kitamura T, Feng Y, Kitamura YI, Chua SC, Jr., Xu AW, Barsh GS, Rossetti L, Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006;12(5):534-40. (Core: MGMB, IB, AEP, AT and HM)

5.   Matsumoto M, Han S, Kitamura T, Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest. 2006;116(9):2464-72. PMCID: 1533874. (Core: AT and MGMB)

6.   Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D. Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J Clin Invest. 2006;116(3):775-82. PMCID: PMC1370178. (Core: AT and MGMB)

7.   Phan LK, Chung WK, Leibel RL. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 2006; 291(3):E611-E620. (Core: MGMB, HM and AT)

8.   Zhang Y, Chen L, Chen N, Yu YH. Expression of monocyte chemoattractant protein-1 is modulated by lipids, but is independent of cell-size and cell-aging. ADIPOCYTE. 2006; 2:37-46 (Core: AT)


(Jan 2007 – Dec, 2007)

9.   Basu R, Pajvani UB, Rizza RA, Scherer PE. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes. 2007; 56:2174-2177. PMCID:PMC17513700 (Core: AT)

10. Buteau J, Shlien A, Foisy S, Accili D. Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1. J Biol Chem. 2007;282(1):287-93. (Core: AT, MGMB and HM)

11. Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L, Loh D, Li C, Chua S, Jr., Zhang Y. Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities. Endocrinology. 2007; 148:3987-3997. (Core: AT and MGMB)

12. Johnson JA, Trasino SE, Ferrante AW, Jr., Vasselli JR. Prolonged Decrease of Adipocyte Size after Rosiglitazone Treatment in High- and Low-Fat-Fed Rats. Obesity (Silver Spring). 2007; 15:2653-2663. (Core: AT, MGMB and HM)

13. Kaplan RC, Ho GY, Xue X, Rajpathak S, Cushman M, Rohan TE, Strickler HD, Scherer PE, Anastos K. Within-individual stability of obesity-related biomarkers among women. Cancer Epidemiol Biomarkers Prev. 2007; 16:1291-1293. (Core: AT)

14. Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest. 2007;117(9):2477-85. PMCID: 1950461. (Core: AT, MGMB and HM)

15. Kusminski CM, McTernan PG, Schraw T, Kos K, O'Hare JP, Ahima R, Kumar S, Scherer PE. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia. 2007; 50:634-642. (Core: AT)

16. Lee M, Kim A, Chua SC, Jr., Obici S, Wardlaw SL. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab. 2007;293(1):E121-31. (Core: AT and MGMB)

17. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456-69. PMCID: 2013746. (Core: AT and MGMB)

18. Li W, Tonelli J, Kishore P, Owen R, Goodman E, Scherer PE, Hawkins M. Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle. Am J Physiol Endocrinol Metab. 2007; 292:E1301-1307. (Core: AT)

19. Lin HV, Kim JY, Pocai A, Rossetti L, Shapiro L, Scherer PE, and Accili D. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic knockout mice. Diabetes 2007. 56:1969-1976. PMID: 17475934. (Core: HM, MGMB, and AT)

20. Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest. 2007; 117:1679-1689. PMCID:PMC1866250 (Core: AT)

21. Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007;6(3):208-16. (Core: AT, MBMG and HM)

22. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Eagle AR, Vats D, Brombacher F, Ferrante AW, Chawla A. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007; 447:1116-1120. PMCID:PMC2587297 (Core: AT, MBMG and HM)

23. Semple RK, Halberg NH, Burling K, Soos MA, Schraw T, Luan J, Cochran EK, Dunger DB, Wareham NJ, Scherer PE, Gorden P, O'Rahilly S. Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes. 2007; 56:1712-1717. PMCID:PMC2253187. (Core: AT)

24. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW, Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006;116(1):115-24. PMCID: 1307559. (Core: AT)

25. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH.  Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes. 2007 Jun;56(6):1647-54. Epub 2007 Mar 14.PMID: 17360978 (Core: AEP, AT and MBMG)


(Jan 2008 – Dec, 2008)

26. Banks AS, Kon N, Knight C, Matsumoto M, Gutierrez-Juarez R, Rossetti L, Gu W, Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008; 8:333-341. (Core: AT, MBMG and HM)

27. Berk E, Johnson JA, Lee MJ, Zhang K, Boozer CN, Pi-Sunyer FX, Fried SK, Albu JB . Higher post-absorptive skeletal muscle LPL-activity in African-American vs. Caucasian pre- menopausal women. Obesity, 16(1):199-201, 2008; (Core: BC HM, AT and BS)

28. Dallaire P, Bellmann K, Laplante M, Gelinas S, Centeno-Baez C, Penfornis P, Peyot ML, Latour MG, Lamontagne J, Trujillo ME, Scherer PE, Prentki M, Deshaies Y, Marette A. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes. 2008; 57:1999-2011. PMCID:PMC2494686 (Core: AT)

29. Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B, Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK, Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008;4(7):e1000137. PMCID: 2464733. (Core: AT, MBMG and HM)

30. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A. 2008;105(13):5266-70. PMCID: 2278202. (Core: AT and MBMG)

31. Korner J, Punyanitya M, Taveras C, McMahon DJ, Kim HJ, Inabnet W, Bessler M, Gallagher D. Sex differences in visceral adipose tissue post-bariatric surgery compared to matched non-surgical controls.  Int J of Body Composition Res. 2008;6:93-9. (Core: AT and MBMG)

32. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW, Jr., Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008; 8:468-481. PMCID:PMC2746325 (Core: AT, HM and MBMG)

33. Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 2008; 7:496-507. PMCID:PMC2587370 (Core: AT, AP, MGMB and HM)

34. Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes. 2008;57(11):2967-76. PMCID: 2570393. (Core: AT and MGMB)

35. Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol. 2008; 294:R1185-1196. PMCID:PMC2808712 (Core: AT and MGMB)

36. Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology. 2008; 149:3549-3558. PMCID:PMC2453081 (Core: AT and MGMB)

(Jan 2009 – Dec, 2009)

37. Guo K, Mogen J, Struzzi S, Zhang Y. Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol. 2009; 296:R1339-1347. PMCID:PMC2689822 (Core: AT and MGMB)

38. Han S, Liang CP, Westerterp M, Senokuchi T, Welch CL, Wang Q, Matsumoto M, Accili D, Tall AR. Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest. 2009;119(4):1029-41. PMCID: 2662550 (Core: AT and MGMB)

39. Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol. 2009; 29:1575-1591. PMCID:PMC2648231 (Core: AT and MGMB)

40. Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.  Diabetes. 2009 Nov;58(11):2516-24. PMID: 19675136. PMCID: 2768165 (Core: AEP and AT)

41. Ortega Martinez de Victoria E, Xu X, Koska J, Francisco AM, Scalise M, Ferrante AW, Jr., Krakoff J. Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians. Diabetes. 2009; 58:385-393. PMCID:PMC2628612 (Core: AT, MBMG and HM)

42. Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med. 2009;15(10):1195-201. PMCID: 2777744. (Core: AT, MBMG, and HM)

43. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ.  Autophagy regulates adipose mass and differentiation in mice.   J Clin Invest. 2009 Nov;119(11):3329-39.  PMID: 19855132 PMCID: PMC2769174 (Core: AEP and AT)

44. Stratigopoulos G, LeDuc CA, Matsuoka N, Gutman R, Rausch R, Robertson SA, Myers MG, Jr., Chung WK, Chua SC, Jr., Leibel RL. Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring). 2009;17(1):126-35. PMCID: 2808713. (Core: AT, MBMG, and HM)

45. Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D. Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes. 2009;58(10):2344-54. PMCID: 2750207. (Core: AT and MGMB)


(Jan 2010 – May, 2010)

46. Goldsmith R, Joanisse DR, Gallagher D, Pavlovich K, Shamoon E, Leibel RL, Rosenbaum M. Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol. 2010;298(1):R79-88. PMCID: 2806213. (Core: AT, BC, MGMB, and HM)

47. Halldorsdottir S, Carmody J, Boozer C, LeDuc C, Leibel R. Reproducibility and Accuracy of Body Composition Assessments in Mice by Dual Energy X-ray Absorptiometry and Time Domain Nuclear Magnetic Resonance. International Journal of Body Composition Research. 2010;In Press. (Core: AT and MGMB)

48. He J, Le DS, Xu X, Scalise M, Ferrante AW, Krakoff J. Circulating white blood cell count and measures of adipose tissue inflammation predict higher 24-h energy expenditure. Eur J Endocrinol. 2010; 162:275-280. (Core: AT and MGMB)

49. Lin HV, Plum L, Ono H, Gutierrez-Juarez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes. 2010;59(2):337-46. PMCID: PMC2809966. (Core: AT and MGMB)

50. Obstfeld AE, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, Ables EV, Ferrante AW, Jr. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes. 2010; 59:916-925. PMCID:PMC2844839 (Core: AT, MGMB and HM)

51. Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest. 2010; 120:357-368. PMCID:PMC2798687 (Core: AT)



Review Articles

(Jan 2006 – Dec 2006)

1.   Leibel RL. The molecular genetics of the melanocortin pathway and energy homeostasis. Cell Metab. 2006;3(2):79-81 (Core: AT and MGMB)


(Jan 2008 – Dec 2008)

2.   Leibel RL. Energy in, energy out, and the effects of obesity-related genes. N Engl J Med. 2008;359(24):2603-4. (Core: AT & MGMB)

(Jan 2010 -  Dec 2010)

3.   I. Tabas , A. Tall, D. Accili (2010). The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ. Res. 106: 58-67. (Core: MBMG and AT)

4.   Zhang Y. Utility of transplantation in studying adipocyte biogenesis and function. Mol Cell Endocrinol. 2010; 318:15-23. PMCID:PMC PMC2826534 (Core: AT)


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